The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2022 Mar 25

PMID 35327350

Authors

Mikhail M Minashkin

Nataliya Y Grigortsevich

Anna S Kamaeva

Valeriya V Barzanova

Alexey A Traspov

Mikhail A Godkov

Farkhad A Ageev

Sergey S Petrikov

Nataliya V Pozdnyakova

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to identify single nucleotide variants in genes associated with susceptibility to or severe outcomes of COVID-19. A total of 319 genomic DNA samples from patients with varying degrees of disease severity and 78 control DNA samples from people who had regular or prolonged contact with patients with COVID-19 but did not have clinical manifestations and/or antibodies to SARS-CoV-2. Seven SNPs were identified that were statistically associated with disease risk or severe course, rs1799864 in the gene (OR = 2.21), rs1990760 in the gene (OR = 2.41), rs1800629 in the gene (OR = 1.98), rs75603675 in the gene (OR = 1.86), rs7842 in the gene (OR = 2.08), rs179008 in the gene (OR = 1.85), rs324011 in the gene (OR = 2.08), rs179008 in the gene (OR = 1.85), and rs324011 in the gene (OR = 1.84), as well as two variants associated with protection from COVID-19, rs744166 in the gene (OR = 0.36) and rs1898830 in the gene (OR = 0.47). The genotype in the region of these markers can be the criterion of the therapeutic approach for patients with COVID-19.

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