Revisiting and Refining Roles of Neural Guidance Cues in Circuit Assembly

Overview

Journal Curr Opin Neurobiol

Specialties Biology
Neurology

Date 2020 Aug 22

PMID 32823181

Citations 15

Authors

Joelle M Dorskind

Alex L Kolodkin

Affiliations

Soon will be listed here.

Abstract

Neural guidance mechanisms ensure the precise targeting and synaptogenesis events essential for normal circuit function. Neuronal growth cones encounter numerous attractive and repulsive cues as they navigate toward their intermediate and final targets; temporal and spatial regulation of these responses are critical for circuit assembly. Recent work highlights the complexity of these events throughout neural development and the multifaceted functions of a wide range of guidance cues. Here, we discuss recent studies that leverage advances in genetics, single cell tracing, transcriptomics and proteomics to further our understanding of the molecular mechanisms underlying neural guidance and overall circuit organization.

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