Tumor Necrosis Factor Alpha/cachectin is a Growth Factor for Thymocytes. Synergistic Interactions with Other Cytokines

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1988 Apr 1

PMID 3282023

Citations 33

Authors

G E Ranges

A Zlotnik

T Espevik

C A Dinarello

A Cerami

M A Palladino Jr

Affiliations

Soon will be listed here.

Abstract

Recombinant murine (rm) TNF-alpha but not recombinant human (rh) TNF-alpha induces the proliferation of murine thymocytes in the presence of a comitogenic stimulus. This effect does not appear to be due to the production of significant levels of IL-1, IL-2, or IL-4. although not directly mitogenic (i.e., in the absence of PHA-P) for thymocytes, rmTNF-alpha amplifies the direct mitogenic signals from hIL-1 and rhIL-2 but not rmIL-4. In the presence of PHA-P, thymocytes stimulated with hIL-1, rhIL-2, and rmIL-4 produced significant amounts of TNF-alpha. Although rhTNF-alpha does not induce a proliferative response, it will competitively inhibit the proliferative response of thymocytes to rmTNF-alpha. These data suggest a critical role for TNF-alpha in the intrathymic proliferation of developing T cells.

Citing Articles

Regulation of intestinal epithelial homeostasis by mesenchymal cells.

Kayama H, Takeda K Inflamm Regen. 2024; 44(1):42.

PMID: 39327633 PMC: 11426228. DOI: 10.1186/s41232-024-00355-0.

Interrogating host immunity to predict treatment response in inflammatory bowel disease.

Digby-Bell J, Atreya R, Monteleone G, Powell N Nat Rev Gastroenterol Hepatol. 2019; 17(1):9-20.

PMID: 31767987 DOI: 10.1038/s41575-019-0228-5.

TNF activity and T cells.

Mehta A, Gracias D, Croft M Cytokine. 2016; 101:14-18.

PMID: 27531077 PMC: 5305780. DOI: 10.1016/j.cyto.2016.08.003.

Effect of hochuekkito on alveolar macrophage inflammatory responses in hyperglycemic mice.

Nakayama M, Sugiyama Y, Yamasawa H, Soda M, Mato N, Hosono T Inflammation. 2012; 35(4):1294-301.

PMID: 22367599 PMC: 3397232. DOI: 10.1007/s10753-012-9441-x.

Interferons alpha/beta inhibit IL-7-induced proliferation of CD4- CD8- CD3- CD44+ CD25+ thymocytes, but do not inhibit that of CD4- CD8- CD3- CD44- CD25- thymocytes.

Su D, Wang J, Lin Q, Cooper M, Watanabe T Immunology. 1997; 90(4):543-9.

PMID: 9176107 PMC: 1456697. DOI: 10.1046/j.1365-2567.1997.00205.x.

References

CARSWELL E, Old L, Kassel R, Green S, Fiore N, Williamson B . An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A. 1975; 72(9):3666-70. PMC: 433057. DOI: 10.1073/pnas.72.9.3666. View

Kramer S, Aggarwal B, Eessalu T, McCabe S, Ferraiolo B, Figari I . Characterization of the in vitro and in vivo species preference of human and murine tumor necrosis factor-alpha. Cancer Res. 1988; 48(4):920-5. View

Gray P, Goeddel D . Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci U S A. 1983; 80(19):5842-6. PMC: 390171. DOI: 10.1073/pnas.80.19.5842. View

Pennica D, Nedwin G, Hayflick J, Seeburg P, Derynck R, Palladino M . Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature. 1984; 312(5996):724-9. DOI: 10.1038/312724a0. View

Beutler B, Mahoney J, Le Trang N, Pekala P, Cerami A . Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. J Exp Med. 1985; 161(5):984-95. PMC: 2187615. DOI: 10.1084/jem.161.5.984. View

Beutler B, Greenwald D, Hulmes J, Chang M, Pan Y, Mathison J . Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature. 1985; 316(6028):552-4. DOI: 10.1038/316552a0. View

Pennica D, Hayflick J, Bringman T, Palladino M, Goeddel D . Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. Proc Natl Acad Sci U S A. 1985; 82(18):6060-4. PMC: 390699. DOI: 10.1073/pnas.82.18.6060. View

Sugarman B, Aggarwal B, Hass P, Figari I, Palladino Jr M, Shepard H . Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science. 1985; 230(4728):943-5. DOI: 10.1126/science.3933111. View

Mosmann T, Cherwinski H, Bond M, Giedlin M, Coffman R . Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986; 136(7):2348-57. View

10.

Peters P, Ortaldo J, Shalaby M, Svedersky L, Nedwin G, Bringman T . Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes. J Immunol. 1986; 137(8):2592-8. View

11.

Espevik T, Nissen-Meyer J . A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J Immunol Methods. 1986; 95(1):99-105. DOI: 10.1016/0022-1759(86)90322-4. View

12.

Beutler B, Cerami A . Cachectin: more than a tumor necrosis factor. N Engl J Med. 1987; 316(7):379-85. DOI: 10.1056/NEJM198702123160705. View

13.

Le J, Weinstein D, Gubler U, Vilcek J . Induction of membrane-associated interleukin 1 by tumor necrosis factor in human fibroblasts. J Immunol. 1987; 138(7):2137-42. View

14.

Cuturi M, Murphy M, Weinmann R, Perussia B, Trinchieri G . Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes. J Exp Med. 1987; 165(6):1581-94. PMC: 2188372. DOI: 10.1084/jem.165.6.1581. View

15.

Zlotnik A, Ransom J, FRANK G, Fischer M, Howard M . Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny. Proc Natl Acad Sci U S A. 1987; 84(11):3856-60. PMC: 304975. DOI: 10.1073/pnas.84.11.3856. View

16.

Zucali J, Elfenbein G, Barth K, Dinarello C . Effects of human interleukin 1 and human tumor necrosis factor on human T lymphocyte colony formation. J Clin Invest. 1987; 80(3):772-7. PMC: 442302. DOI: 10.1172/JCI113133. View

17.

Conlon P, Henney C, Gillis S . Cytokine-dependent thymocyte responses: characterization of IL 1 and IL 2 target subpopulations and mechanism of action. J Immunol. 1982; 128(2):797-801. View