Hypertension, Heart Failure, and Frailty in Older People: A Common but Unclear Situation

Overview

Journal J Clin Hypertens (Greenwich)

Specialty Cardiology & Vascular Diseases

Date 2020 Aug 21

PMID 32815630

Citations 14

Authors

Miguel Camafort

Kazuomi Kario

Affiliations

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Abstract

Hypertension and heart failure are common conditions in older people. Comorbidity, together with aging, is commonly associated with frailty, which is a cause of a worse prognosis, more hospitalizations, increased dependency, and mortality. Despite being increasingly common conditions, data on the prevalence and influence of frailty in hypertensive older patients with HF are lacking. This may be due to the multidimensional aspects of frailty and the differing tools used to evaluate it. Nevertheless, in clinical practice, it is common to see frail hypertensive patients with HF but the specific characteristics of this group of patients, including multimorbidity and frailty, and the lack of data from registries or randomized clinical trials make the diagnosis and management of these patients more difficult than in those of other ages. This review focuses on what is known and on where future investigations should focus in this common but unclear situation.

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References

Bastos-Barbosa R, Ferriolli E, Coelho E, Moriguti J, Nobre F, Lima N . Association of frailty syndrome in the elderly with higher blood pressure and other cardiovascular risk factors. Am J Hypertens. 2012; 25(11):1156-61. DOI: 10.1038/ajh.2012.99. View

Camafort M, Kario K . Hypertension, heart failure, and frailty in older people: A common but unclear situation. J Clin Hypertens (Greenwich). 2020; 22(10):1763-1768. PMC: 8029958. DOI: 10.1111/jch.14004. View

Ma L, Zhang L, Sun F, Li Y, Tang Z . Frailty in Chinese older adults with hypertension: Prevalence, associated factors, and prediction for long-term mortality. J Clin Hypertens (Greenwich). 2018; 20(11):1595-1602. PMC: 8031324. DOI: 10.1111/jch.13405. View

Vetrano D, Palmer K, Galluzzo L, Giampaoli S, Marengoni A, Bernabei R . Hypertension and frailty: a systematic review and meta-analysis. BMJ Open. 2018; 8(12):e024406. PMC: 6318510. DOI: 10.1136/bmjopen-2018-024406. View

Ogliari G, Westendorp R, Muller M, Mari D, Torresani E, Felicetta I . Blood pressure and 10-year mortality risk in the Milan Geriatrics 75+ Cohort Study: role of functional and cognitive status. Age Ageing. 2015; 44(6):932-7. DOI: 10.1093/ageing/afv141. View

Gorodeski E, Goyal P, Hummel S, Krishnaswami A, Goodlin S, Hart L . Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future. J Am Coll Cardiol. 2018; 71(17):1921-1936. PMC: 7304050. DOI: 10.1016/j.jacc.2018.02.059. View

Fujiwara T, Hoshide S, Kanegae H, Kario K . Prognostic Value of a Riser Pattern of Nighttime Blood Pressure in Very Elderly Adults of ≥80 Years: A General Practice-Based Prospective SEARCH Study. Am J Hypertens. 2020; 33(6):520-527. DOI: 10.1093/ajh/hpz197. View

Lordos E, Herrmann F, Robine J, Balahoczky M, Giannelli S, Gold G . Comparative value of medical diagnosis versus physical functioning in predicting the 6-year survival of 1951 hospitalized old patients. Rejuvenation Res. 2008; 11(4):829-36. DOI: 10.1089/rej.2008.0721. View

Sze S, Pellicori P, Zhang J, Weston J, Clark A . Identification of Frailty in Chronic Heart Failure. JACC Heart Fail. 2019; 7(4):291-302. DOI: 10.1016/j.jchf.2018.11.017. View

10.

Narita K, Hoshide S, Kario K . Improvement of Actisensitivity After Ventricular Reverse Remodeling in Heart Failure: New ICT-Based Multisensor Ambulatory Blood Pressure Monitoring. Am J Hypertens. 2019; 33(2):161-164. DOI: 10.1093/ajh/hpz177. View

11.

Ziaeian B, Fonarow G . Epidemiology and aetiology of heart failure. Nat Rev Cardiol. 2016; 13(6):368-78. PMC: 4868779. DOI: 10.1038/nrcardio.2016.25. View

12.

Beard J, Officer A, Araujo de Carvalho I, Sadana R, Pot A, Michel J . The World report on ageing and health: a policy framework for healthy ageing. Lancet. 2015; 387(10033):2145-2154. PMC: 4848186. DOI: 10.1016/S0140-6736(15)00516-4. View

13.

Bulpitt C, Beckett N, Peters R, Staessen J, Wang J, Comsa M . Does white coat hypertension require treatment over age 80?: Results of the hypertension in the very elderly trial ambulatory blood pressure side project. Hypertension. 2012; 61(1):89-94. DOI: 10.1161/HYPERTENSIONAHA.112.191791. View

14.

Ponikowski P, Voors A, Anker S, Bueno H, Cleland J, Coats A . 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special.... Eur Heart J. 2016; 37(27):2129-2200. DOI: 10.1093/eurheartj/ehw128. View

15.

Rockwood K, Song X, MacKnight C, Bergman H, Hogan D, McDowell I . A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005; 173(5):489-95. PMC: 1188185. DOI: 10.1503/cmaj.050051. View

16.

Williamson J, Supiano M, Applegate W, Berlowitz D, Campbell R, Chertow G . Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial. JAMA. 2016; 315(24):2673-82. PMC: 4988796. DOI: 10.1001/jama.2016.7050. View

17.

Butler J, Kalogeropoulos A, Georgiopoulou V, Bibbins-Domingo K, Najjar S, Sutton-Tyrrell K . Systolic blood pressure and incident heart failure in the elderly. The Cardiovascular Health Study and the Health, Ageing and Body Composition Study. Heart. 2011; 97(16):1304-11. PMC: 3652313. DOI: 10.1136/hrt.2011.225482. View

18.

Gulland A . Global life expectancy increases by five years. BMJ. 2016; 353:i2883. DOI: 10.1136/bmj.i2883. View

19.

Komori T, Eguchi K, Saito T, Hoshide S, Kario K . Riser Pattern Is a Novel Predictor of Adverse Events in Heart Failure Patients With Preserved Ejection Fraction. Circ J. 2016; 81(2):220-226. DOI: 10.1253/circj.CJ-16-0740. View

20.

Vitale C, Jankowska E, Hill L, Piepoli M, Doehner W, Anker S . Heart Failure Association/European Society of Cardiology position paper on frailty in patients with heart failure. Eur J Heart Fail. 2019; 21(11):1299-1305. DOI: 10.1002/ejhf.1611. View