Autophagy in Osteosarcoma

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2020 Aug 9

PMID 32767241

Citations 7

Authors

Grace Nehme

Nancy Gordon

Affiliations

Soon will be listed here.

Abstract

Osteosarcoma (OS) remains a difficult disease to treat. The standard chemotherapy regimen has not improved survival for the past three decades. Resistance to chemotherapy remains a challenge and constitutes a major concern to clinical investigators. Autophagy has been recognized as a survival mechanism implicated in resistance to chemotherapy. We previously demonstrated chemotherapy to induce autophagy in OS. However, whether induction of autophagy will lead to survival or death has been the focus of many laboratories. Autophagy is a very context-dependent process, and no specific biomarker has been identified to define whether the process will lead to survival or death. In the present chapter, we present some of the mechanisms involved in the process of autophagy and summarize some of the most recent work related to autophagy in OS and the challenges encountered with the use of old and new autophagy inhibitors.

Citing Articles

Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis.

Shang J, Zhao F, Xie L, Wang Y, Li B, Jin C Open Med (Wars). 2024; 19(1):20241080.

PMID: 39655055 PMC: 11627063. DOI: 10.1515/med-2024-1080.

The role of programmed cell death in osteosarcoma: From pathogenesis to therapy.

Liu S, Liu C, Wang Y, Chen J, He Y, Hu K Cancer Med. 2024; 13(10):e7303.

PMID: 38800967 PMC: 11129166. DOI: 10.1002/cam4.7303.

Epigenetic Changes Associated with Osteosarcoma: A Comprehensive Review.

Twenhafel L, Moreno D, Punt T, Kinney M, Ryznar R Cells. 2023; 12(12).

PMID: 37371065 PMC: 10297049. DOI: 10.3390/cells12121595.

Construction and validation of a prognostic model for osteosarcoma patients based on autophagy-related genes.

Ning B, Liu Y, Xu T, Li Y, Wei D, Huang T Discov Oncol. 2022; 13(1):146.

PMID: 36586072 PMC: 9805482. DOI: 10.1007/s12672-022-00608-9.

Effects of microenvironment in osteosarcoma on chemoresistance and the promise of immunotherapy as an osteosarcoma therapeutic modality.

Yu L, Zhang J, Li Y Front Immunol. 2022; 13:871076.

PMID: 36311748 PMC: 9608329. DOI: 10.3389/fimmu.2022.871076.

References

Towers C, Thorburn A . Therapeutic Targeting of Autophagy. EBioMedicine. 2016; 14:15-23. PMC: 5161418. DOI: 10.1016/j.ebiom.2016.10.034. View

Kang R, Livesey K, Zeh H, Loze M, Tang D . HMGB1: a novel Beclin 1-binding protein active in autophagy. Autophagy. 2010; 6(8):1209-11. DOI: 10.4161/auto.6.8.13651. View

Rangwala R, Leone R, Chang Y, Fecher L, Schuchter L, Kramer A . Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma. Autophagy. 2014; 10(8):1369-79. PMC: 4203514. DOI: 10.4161/auto.29118. View

Fulda S, Kogel D . Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy. Oncogene. 2015; 34(40):5105-13. DOI: 10.1038/onc.2014.458. View

Santiago-OFarrill J, Kleinerman E, Hollomon M, Livingston A, Wang W, Tsai J . Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy. Oncotarget. 2018; 9(2):1602-1616. PMC: 5788585. DOI: 10.18632/oncotarget.20308. View

Xiao X, Wang W, Li Y, Yang D, Li X, Shen C . HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma. J Exp Clin Cancer Res. 2018; 37(1):201. PMC: 6114771. DOI: 10.1186/s13046-018-0880-6. View

Li L, Xie W, Pan D, Chen H, Zhang L . Inhibition of autophagy by bafilomycin A1 promotes chemosensitivity of gastric cancer cells. Tumour Biol. 2015; 37(1):653-9. DOI: 10.1007/s13277-015-3842-z. View

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H . Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011; 25(7):717-29. PMC: 3070934. DOI: 10.1101/gad.2016111. View

Seglen P, Gordon P . 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A. 1982; 79(6):1889-92. PMC: 346086. DOI: 10.1073/pnas.79.6.1889. View

10.

Chiu H, Lin W, Ho S, Wang Y . Synergistic effects of arsenic trioxide and radiation in osteosarcoma cells through the induction of both autophagy and apoptosis. Radiat Res. 2011; 175(5):547-60. DOI: 10.1667/RR2380.1. View

11.

Karch J, Schips T, Maliken B, Brody M, Sargent M, Kanisicak O . Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. Elife. 2017; 6. PMC: 5697932. DOI: 10.7554/eLife.30543. View

12.

Rosenfeld M, Ye X, Supko J, Desideri S, Grossman S, Brem S . A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy. 2014; 10(8):1359-68. PMC: 4203513. DOI: 10.4161/auto.28984. View

13.

Liu Q, Thoreen C, Wang J, Sabatini D, Gray N . mTOR Mediated Anti-Cancer Drug Discovery. Drug Discov Today Ther Strateg. 2010; 6(2):47-55. PMC: 2901551. DOI: 10.1016/j.ddstr.2009.12.001. View

14.

Shao S, Li S, Qin Y, Wang X, Yang Y, Bai H . Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int J Oncol. 2014; 44(5):1661-8. PMC: 6904104. DOI: 10.3892/ijo.2014.2313. View

15.

Bao X, Zhao L, Guan H, Li F . Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma. Cell Death Dis. 2018; 9(6):611. PMC: 5966512. DOI: 10.1038/s41419-018-0620-z. View

16.

Zhu X, Yang G, Xu J, Zhang C . Silencing of SNHG6 induced cell autophagy by targeting miR-26a-5p/ULK1 signaling pathway in human osteosarcoma. Cancer Cell Int. 2019; 19:82. PMC: 6448242. DOI: 10.1186/s12935-019-0794-1. View

17.

Li B, Ye Z . Epigenetic alterations in osteosarcoma: promising targets. Mol Biol Rep. 2014; 41(5):3303-15. DOI: 10.1007/s11033-014-3193-7. View

18.

Shimizu S, Yoshida T, Tsujioka M, Arakawa S . Autophagic cell death and cancer. Int J Mol Sci. 2014; 15(2):3145-53. PMC: 3958902. DOI: 10.3390/ijms15023145. View

19.

Chen Y, Wang S, Geng B, Yi Z . Pelargonidin induces antitumor effects in human osteosarcoma cells via autophagy induction, loss of mitochondrial membrane potential, G2/M cell cycle arrest and downregulation of PI3K/AKT signalling pathway. J BUON. 2018; 23(3):735-740. View

20.

Sakamaki J, Long J, New M, Van Acker T, Tooze S, Ryan K . Emerging roles of transcriptional programs in autophagy regulation. Transcription. 2017; 9(2):131-136. PMC: 5834222. DOI: 10.1080/21541264.2017.1372045. View