Trends and Future Directions of Autophagy in Osteosarcoma: A Bibliometric Analysis

Overview

Journal Open Med (Wars)

Specialty General Medicine

Date 2024 Dec 10

PMID 39655055

Authors

JinXiang Shang

FeiYing Zhao

Lu Xie

Yaqing Wang

Bo Li

Cong Jin

Affiliations

Soon will be listed here.

Abstract

Background: Osteosarcoma, a highly malignant skeletal tumor, primarily affects children and adolescents. Autophagy plays a crucial role in osteosarcoma pathophysiology. This study utilizes bibliometric analysis to evaluate current research on autophagy in osteosarcoma and forecast future directions.

Methods: We conducted a comprehensive search of publications in the Web of Science Core Collection database from January 1, 2008, to March 15, 2024. Tools like VOSviewer, CiteSpace, R software, Excel, and Scimago were used for analysis and visualization.

Results: Publications increased steadily over 17 years, indicating rising interest. Zhang Yuan was the most influential author, with Shanghai Jiao Tong University leading. was the top journal. "HMGB1 Promotes Drug Resistance in Osteosarcoma" was the most cited paper. Co-cited articles focused on drug resistance, therapeutic targets, autophagy in cancer, and genomic impacts on immunotherapy. Keywords highlighted invasion, migration, cell death, and breast cancer as research hotspots. Future studies will likely focus on therapeutic innovations and integrated management strategies.

Conclusion: This bibliometric analysis offers an overview of current knowledge and emerging trends in autophagy and osteosarcoma, emphasizing key areas like invasion, migration, and cell death. It serves as a valuable resource for researchers developing novel therapies for osteosarcoma.

References

Huang J, Ni J, Liu K, Yu Y, Xie M, Kang R . HMGB1 promotes drug resistance in osteosarcoma. Cancer Res. 2011; 72(1):230-8. DOI: 10.1158/0008-5472.CAN-11-2001. View

Zhang T, Zhang B, Tian W, Ma X, Wang F, Wang P . A Bibliometric Analysis of Atrophic Gastritis From 2011 to 2021. Front Med (Lausanne). 2022; 9:843395. PMC: 8891522. DOI: 10.3389/fmed.2022.843395. View

Usman R, Razzaq F, Akbar A, Farooqui A, Iftikhar A, Latif A . Role and mechanism of autophagy-regulating factors in tumorigenesis and drug resistance. Asia Pac J Clin Oncol. 2020; 17(3):193-208. DOI: 10.1111/ajco.13449. View

Li H, Zhang J, Sun L, Li B, Gao H, Xie T . Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study. Cell Death Dis. 2015; 6:e1604. PMC: 4669742. DOI: 10.1038/cddis.2014.543. View

Zhao G, Gao Z, Zhang Q, Tang X, Lv Y, Zhang Z . TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis. J Exp Clin Cancer Res. 2018; 37(1):188. PMC: 6085607. DOI: 10.1186/s13046-018-0856-6. View

Eaton B, Schwarz R, Vatner R, Yeh B, Claude L, Indelicato D . Osteosarcoma. Pediatr Blood Cancer. 2020; 68 Suppl 2:e28352. DOI: 10.1002/pbc.28352. View

Isakoff M, Bielack S, Meltzer P, Gorlick R . Osteosarcoma: Current Treatment and a Collaborative Pathway to Success. J Clin Oncol. 2015; 33(27):3029-35. PMC: 4979196. DOI: 10.1200/JCO.2014.59.4895. View

Ma K, Zhang C, Huang M, Li W, Hu G . Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway. Oncol Rep. 2016; 36(1):90-8. PMC: 4899018. DOI: 10.3892/or.2016.4782. View

Kim H, Lee S, Kim Y, Park J, Lee K, Yoo Y . Cytoprotective role of autophagy during paclitaxel-induced apoptosis in Saos-2 osteosarcoma cells. Int J Oncol. 2013; 42(6):1985-92. DOI: 10.3892/ijo.2013.1884. View

10.

Agrawal Y, Nadkarni K, Gupta N, Manne R, Santra M . F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells. Toxicol Appl Pharmacol. 2022; 441:115973. DOI: 10.1016/j.taap.2022.115973. View

11.

Prigione A, Cortopassi G . Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12. Autophagy. 2007; 3(4):377-80. DOI: 10.4161/auto.4239. View

12.

Ritter J, Bielack S . Osteosarcoma. Ann Oncol. 2010; 21 Suppl 7:vii320-5. DOI: 10.1093/annonc/mdq276. View

13.

Onorati A, Dyczynski M, Ojha R, Amaravadi R . Targeting autophagy in cancer. Cancer. 2018; 124(16):3307-3318. PMC: 6108917. DOI: 10.1002/cncr.31335. View

14.

Luo M, Su Z, Gao H, Tan J, Liao R, Yang J . Cirsiliol induces autophagy and mitochondrial apoptosis through the AKT/FOXO1 axis and influences methotrexate resistance in osteosarcoma. J Transl Med. 2023; 21(1):907. PMC: 10714637. DOI: 10.1186/s12967-023-04682-7. View

15.

Ning B, Liu Y, Huang T, Wei Y . Autophagy and its role in osteosarcoma. Cancer Med. 2023; 12(5):5676-5687. PMC: 10028045. DOI: 10.1002/cam4.5407. View

16.

Jafari F, Javdansirat S, Sanaie S, Naseri A, Shamekh A, Rostamzadeh D . Osteosarcoma: A comprehensive review of management and treatment strategies. Ann Diagn Pathol. 2020; 49:151654. DOI: 10.1016/j.anndiagpath.2020.151654. View

17.

Levine B, Kroemer G . Autophagy in the pathogenesis of disease. Cell. 2008; 132(1):27-42. PMC: 2696814. DOI: 10.1016/j.cell.2007.12.018. View

18.

Xie C, Liu S, Wu B, Zhao Y, Chen B, Guo J . miR-19 Promotes Cell Proliferation, Invasion, Migration, and EMT by Inhibiting SPRED2-mediated Autophagy in Osteosarcoma Cells. Cell Transplant. 2020; 29:963689720962460. PMC: 7784565. DOI: 10.1177/0963689720962460. View

19.

Huang L, Chen Q, Yu L, Bai D . Pyropheophorbide-α methyl ester-mediated photodynamic therapy induces apoptosis and inhibits LPS-induced inflammation in RAW264.7 macrophages. Photodiagnosis Photodyn Ther. 2018; 25:148-156. DOI: 10.1016/j.pdpdt.2018.12.002. View

20.

Hu F, Song D, Yan Y, Huang C, Shen C, Lan J . IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021; 12(1):3651. PMC: 8206314. DOI: 10.1038/s41467-021-23923-1. View