Approaches and Technologies in Male Fertility Preservation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Aug 6

PMID 32751826

Citations 12

Authors

Mahmoud Huleihel

Eitan Lunenfeld

Affiliations

Soon will be listed here.

Abstract

Male fertility preservation is required when treatment with an aggressive chemo-/-radiotherapy, which may lead to irreversible sterility. Due to new and efficient protocols of cancer treatments, surviving rates are more than 80%. Thus, these patients are looking forward to family life and fathering their own biological children after treatments. Whereas adult men can cryopreserve their sperm for future use in assistance reproductive technologies (ART), this is not an option in prepubertal boys who cannot produce sperm at this age. In this review, we summarize the different technologies for male fertility preservation with emphasize on prepubertal, which have already been examined and/or demonstrated in vivo and/or in vitro using animal models and, in some cases, using human tissues. We discuss the limitation of these technologies for use in human fertility preservation. This update review can assist physicians and patients who are scheduled for aggressive chemo-/radiotherapy, specifically prepubertal males and their parents who need to know about the risks of the treatment on their future fertility and the possible present option of fertility preservation.

Citing Articles

Fertility preservation in men with hypogonadotropic hypogonadism secondary to germinoma: two cases of gonadotropin replacement therapy before induction of anticancer chemotherapy.

Kaku Y, Chiba K, Yamashita Y, Kawamura S, Sato K, Hara T Int Cancer Conf J. 2024; 13(4):468-470.

PMID: 39398912 PMC: 11464966. DOI: 10.1007/s13691-024-00711-4.

Elucidating the Transcriptional States of Spermatogenesis-Joint Analysis of Germline and Supporting Cell, Mice and Human, Normal and Perturbed, Bulk and Single-Cell RNA-Seq.

AbuMadighem A, Cohen O, Huleihel M Biomolecules. 2024; 14(7).

PMID: 39062554 PMC: 11274546. DOI: 10.3390/biom14070840.

Effect of Temperature on the Development of Stages of Spermatogenesis and the Functionality of Sertoli Cells In Vitro.

Jorban A, Lunenfeld E, Huleihel M Int J Mol Sci. 2024; 25(4).

PMID: 38396838 PMC: 10889116. DOI: 10.3390/ijms25042160.

In vitro spermatogenesis in artificial testis: current knowledge and clinical implications for male infertility.

Bashiri Z, Gholipourmalekabadi M, Khadivi F, Salem M, Afzali A, Cham T Cell Tissue Res. 2023; 394(3):393-421.

PMID: 37721632 DOI: 10.1007/s00441-023-03824-z.

Effect of Granulocyte Colony-Stimulating Factor on the Development of Spermatogenesis in the Adulthood of Juvenile AML Mice Model Treated with Cytarabine.

Khaleel B, Lunenfeld E, Kapelushnik J, Huleihel M Int J Mol Sci. 2023; 24(15).

PMID: 37569605 PMC: 10419160. DOI: 10.3390/ijms241512229.

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