Spermatogenesis Following Male Germ-cell Transplantation

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Nov 22

PMID 7972053

Citations 483

Authors

R L Brinster

J W Zimmermann

Affiliations

Soon will be listed here.

Abstract

In the adult male, a population of diploid stem-cell spermatogonia continuously undergoes self-renewal and produces progeny cells, which initiate the complex process of cellular differentiation that results in mature spermatozoa. We report here that stem cells isolated from testes of donor male mice will repopulate sterile testes when injected into seminiferous tubules. Donor cell spermatogenesis in recipient testes showed normal morpholigical characteristics and produced mature spermatozoa. This methodology, besides opening new avenues of basic research into spermatogenesis and stem-cell self-renewal, may prove useful as a tool for biomedical science and biotechnology.

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