Histone Variants in Skeletal Myogenesis

Overview

Journal Epigenetics

Specialty Genetics

Date 2020 Jul 21

PMID 32686575

Citations 3

Authors

Nandini Karthik

Reshma Taneja

Affiliations

Soon will be listed here.

Abstract

Histone variants regulate chromatin accessibility and gene transcription. Given their distinct properties and functions, histone varint substitutions allow for profound alteration of nucleosomal architecture and local chromatin landscape. Skeletal myogenesis driven by the key transcription factor MyoD is characterized by precise temporal regulation of myogenic genes. Timed substitution of variants within the nucleosomes provides a powerful means to ensure sequential expression of myogenic genes. Indeed, growing evidence has shown H3.3, H2A.Z, macroH2A, and H1b to be critical for skeletal myogenesis. However, the relative importance of various histone variants and their associated chaperones in myogenesis is not fully appreciated. In this review, we summarize the role that histone variants play in altering chromatin landscape to ensure proper muscle differentiation. The temporal regulation and cross talk between histones variants and their chaperones in conjunction with other forms of epigenetic regulation could be critical to understanding myogenesis and their involvement in myopathies.

Citing Articles

The Function of H2A Histone Variants and Their Roles in Diseases.

Yin X, Zeng D, Liao Y, Tang C, Li Y Biomolecules. 2024; 14(8).

PMID: 39199381 PMC: 11352661. DOI: 10.3390/biom14080993.

An interplay between BRD4 and G9a regulates skeletal myogenesis.

Yang N, Das D, Shankar S, Goy P, Guccione E, Taneja R Front Cell Dev Biol. 2022; 10:978931.

PMID: 36158208 PMC: 9489841. DOI: 10.3389/fcell.2022.978931.

Epigenetic Regulation of Myogenesis: Focus on the Histone Variants.

de Lima J, Relaix F Int J Mol Sci. 2021; 22(23).

PMID: 34884532 PMC: 8657657. DOI: 10.3390/ijms222312727.

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