Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2020 Jul 21

PMID 32686218

Citations 16

Authors

Shuai Jiang

Ming Xiao

Wen Sun

Daniel Crespy

Volker Mailander

Xiaojun Peng

Jiangli Fan

Katharina Landfester

Affiliations

Soon will be listed here.

Abstract

The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O produced by the PDT is converted to H O by superoxide dismutase, followed by the transformation of H O to the highly toxic OH via Fenton reactions by Fe originating from the dissolution of co-loaded Fe O nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus-even for drug-resistant cells. Cisplatin generates O in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O source for production of OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.

Citing Articles

Non-discriminating engineered masking of immuno-evasive ligands on tumour-derived extracellular vesicles enhances tumour vaccination outcomes.

Ding X, Zhang J, Wan S, Wang X, Wang Z, Pu K Nat Nanotechnol. 2024; 20(1):156-166.

PMID: 39327512 DOI: 10.1038/s41565-024-01783-2.

Advances in Delivering Oxidative Modulators for Disease Therapy.

Yang W, Yue H, Lu G, Wang W, Deng Y, Ma G Research (Wash D C). 2024; 2022:9897464.

PMID: 39070608 PMC: 11278358. DOI: 10.34133/2022/9897464.

Aptamer-Based Smart Targeting and Spatial Trigger-Response Drug-Delivery Systems for Anticancer Therapy.

Park D, Lee S, Park J Biomedicines. 2024; 12(1).

PMID: 38255292 PMC: 10813750. DOI: 10.3390/biomedicines12010187.

The Amplified DNA Logic Gates Based on Aptamer-Receptor Recognition for Cell Detection and Bioimaging.

Wang Y, Wu D, Cao X, Guo Y Biosensors (Basel). 2023; 13(11).

PMID: 37998143 PMC: 10669702. DOI: 10.3390/bios13110968.

Activity-based bioluminescence probes for in vivo sensing applications.

Yadav A, Chan J Curr Opin Chem Biol. 2023; 74:102310.

PMID: 37119771 PMC: 10225331. DOI: 10.1016/j.cbpa.2023.102310.

References

Mehraban N, Freeman H . Developments in PDT Sensitizers for Increased Selectivity and Singlet Oxygen Production. Materials (Basel). 2017; 8(7):4421-4456. PMC: 5455656. DOI: 10.3390/ma8074421. View

Jiang Y, Zhao X, Huang J, Li J, Upputuri P, Sun H . Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy. Nat Commun. 2020; 11(1):1857. PMC: 7170847. DOI: 10.1038/s41467-020-15730-x. View

Sullivan R, Graham C . Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev. 2007; 26(2):319-31. DOI: 10.1007/s10555-007-9062-2. View

Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin D, Pineros M . Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2018; 144(8):1941-1953. DOI: 10.1002/ijc.31937. View

Jung H, Han J, Shi H, Koo S, Singh H, Kim H . Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach. J Am Chem Soc. 2017; 139(22):7595-7602. PMC: 5772932. DOI: 10.1021/jacs.7b02396. View

Cheng Y, Cheng H, Jiang C, Qiu X, Wang K, Huan W . Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy. Nat Commun. 2015; 6:8785. PMC: 4659941. DOI: 10.1038/ncomms9785. View

Shen S, Zhu C, Huo D, Yang M, Xue J, Xia Y . A Hybrid Nanomaterial for the Controlled Generation of Free Radicals and Oxidative Destruction of Hypoxic Cancer Cells. Angew Chem Int Ed Engl. 2017; 56(30):8801-8804. PMC: 5543408. DOI: 10.1002/anie.201702898. View

Petrova V, Annicchiarico-Petruzzelli M, Melino G, Amelio I . The hypoxic tumour microenvironment. Oncogenesis. 2018; 7(1):10. PMC: 5833859. DOI: 10.1038/s41389-017-0011-9. View

Chen Q, Feng L, Liu J, Zhu W, Dong Z, Wu Y . Intelligent Albumin-MnO2 Nanoparticles as pH-/H2 O2 -Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy. Adv Mater. 2016; 28(33):7129-36. DOI: 10.1002/adma.201601902. View

10.

Xu J, Xu L, Wang C, Yang R, Zhuang Q, Han X . Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer. ACS Nano. 2017; 11(5):4463-4474. DOI: 10.1021/acsnano.7b00715. View

11.

Liu K, Xing R, Zou Q, Ma G, Mohwald H, Yan X . Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy. Angew Chem Int Ed Engl. 2016; 55(9):3036-9. DOI: 10.1002/anie.201509810. View

12.

Ding B, Shao S, Yu C, Teng B, Wang M, Cheng Z . Large-Pore Mesoporous-Silica-Coated Upconversion Nanoparticles as Multifunctional Immunoadjuvants with Ultrahigh Photosensitizer and Antigen Loading Efficiency for Improved Cancer Photodynamic Immunotherapy. Adv Mater. 2018; 30(52):e1802479. DOI: 10.1002/adma.201802479. View

13.

Xing L, Gong J, Wang Y, Zhu Y, Huang Z, Zhao J . Hypoxia alleviation-triggered enhanced photodynamic therapy in combination with IDO inhibitor for preferable cancer therapy. Biomaterials. 2019; 206:170-182. DOI: 10.1016/j.biomaterials.2019.03.027. View

14.

Zhang L, Wan S, Li C, Xu L, Cheng H, Zhang X . An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied HO and Acceleration of Fe(III)/Fe(II) Conversion. Nano Lett. 2018; 18(12):7609-7618. DOI: 10.1021/acs.nanolett.8b03178. View

15.

Song G, Liang C, Yi X, Zhao Q, Cheng L, Yang K . Perfluorocarbon-Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer. Adv Mater. 2016; 28(14):2716-23. DOI: 10.1002/adma.201504617. View

16.

Abraham J, Salama N, Azab A . The role of P-glycoprotein in drug resistance in multiple myeloma. Leuk Lymphoma. 2014; 56(1):26-33. DOI: 10.3109/10428194.2014.907890. View

17.

Fan W, Yung B, Huang P, Chen X . Nanotechnology for Multimodal Synergistic Cancer Therapy. Chem Rev. 2017; 117(22):13566-13638. DOI: 10.1021/acs.chemrev.7b00258. View

18.

Li J, Pu K . Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer. Acc Chem Res. 2020; 53(4):752-762. DOI: 10.1021/acs.accounts.9b00569. View

19.

He C, Duan X, Guo N, Chan C, Poon C, Weichselbaum R . Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy. Nat Commun. 2016; 7:12499. PMC: 4992065. DOI: 10.1038/ncomms12499. View

20.

Li M, Xia J, Tian R, Wang J, Fan J, Du J . Near-Infrared Light-Initiated Molecular Superoxide Radical Generator: Rejuvenating Photodynamic Therapy against Hypoxic Tumors. J Am Chem Soc. 2018; 140(44):14851-14859. DOI: 10.1021/jacs.8b08658. View