Advances in Omic Studies Drive Discoveries in the Biology of Anisakid Nematodes

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2020 Jul 19

PMID 32679891

Citations 10

Authors

Stefano DAmelio

Fabrizio Lombardo

Antonella Pizzarelli

Ilaria Bellini

Serena Cavallero

Affiliations

Soon will be listed here.

Abstract

Advancements in technologies employed in high-throughput next-generation sequencing (NGS) methods are supporting the spread of studies that, combined with advances in computational biology and bioinformatics, have greatly accelerated discoveries within basic and biomedical research for many parasitic diseases. Here, we review the most updated "omic" studies performed on anisakid nematodes, a family of marine parasites that are causative agents of the fish-borne zoonosis known as anisakiasis or anisakidosis. Few deposited data on genomes are so far available, and this still hinders the deep and highly accurate characterization of biological aspects of interest, even as several transcriptomic and proteomic studies are becoming available. These have been aimed at discovering and characterizing molecules specific to peculiar developmental parasitic stages or tissues, as well as transcripts with pathogenic potential as toxins and allergens, with a broad relevance for a better understanding of host-pathogen relationships and for the development of reliable diagnostic tools.

Citing Articles

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PMID: 36297271 PMC: 9611079. DOI: 10.3390/pathogens11101214.

What Do In Vitro and In Vivo Models Tell Us about Anisakiasis? New Tools Still to Be Explored.

Cavallero S, Bellini I, Pizzarelli A, DAmelio S Pathogens. 2022; 11(3).

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Proteomic Profiling and In Silico Characterization of the Secretome of Sensu Stricto L3 Larvae.

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Cavallero S, Lombardo F, DAmelio S Genes (Basel). 2021; 12(8).

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