Genomics of the Parasitic Nematode and Its Relatives

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Apr 3

PMID 33800545

Citations 14

Authors

Jianbin Wang

Affiliations

Soon will be listed here.

Abstract

Nematodes of the genus are important parasites of humans and swine, and the phylogenetically related genera (, and infect mammals of veterinary interest. Over the last decade, considerable genomic resources have been established for , including complete germline and somatic genomes, comprehensive mRNA and small RNA transcriptomes, as well as genome-wide histone and chromatin data. These datasets provide a major resource for studies on the basic biology of these parasites and the host-parasite relationship. and its relatives undergo programmed DNA elimination, a highly regulated process where chromosomes are fragmented and portions of the genome are lost in embryonic cells destined to adopt a somatic fate, whereas the genome remains intact in germ cells. Unlike many model organisms, transcription drives early development beginning prior to pronuclear fusion. Studies on demonstrated a complex small RNA network even in the absence of a piRNA pathway. Comparative genomics of these ascarids has provided perspectives on nematode sex chromosome evolution, programmed DNA elimination, and host-parasite coevolution. The genomic resources enable comparison of proteins across diverse species, revealing many new potential drug targets that could be used to control these parasitic nematodes.

Citing Articles

Assessing parasite genomes assembled using only Oxford Nanopore Technologies MinION data.

Herzog K, Wu R, Hawdon J, Nejsum P, Fauver J iScience. 2024; 27(9):110614.

PMID: 39211578 PMC: 11357801. DOI: 10.1016/j.isci.2024.110614.

End resection and telomere healing of DNA double-strand breaks during nematode programmed DNA elimination.

Estrem B, Davis R, Wang J Nucleic Acids Res. 2024; 52(15):8913-8929.

PMID: 38953168 PMC: 11347171. DOI: 10.1093/nar/gkae579.

Chromosome fusion and programmed DNA elimination shape karyotypes of nematodes.

Simmons J, Estrem B, Zagoskin M, Oldridge R, Zadegan S, Wang J Curr Biol. 2024; 34(10):2147-2161.e5.

PMID: 38688284 PMC: 11111355. DOI: 10.1016/j.cub.2024.04.022.

End resection and telomere healing of DNA double-strand breaks during nematode programmed DNA elimination.

Estrem B, Davis R, Wang J bioRxiv. 2024; .

PMID: 38559121 PMC: 10980081. DOI: 10.1101/2024.03.15.585292.

Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids.

Wolstenholme A, Andersen E, Choudhary S, Ebner F, Hartmann S, Holden-Dye L Adv Parasitol. 2024; 123:51-123.

PMID: 38448148 PMC: 11143470. DOI: 10.1016/bs.apar.2023.12.002.

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