Cytokine Storms: Understanding COVID-19

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2020 Jul 2

PMID 32610079

Citations 364

Authors

Nilam Mangalmurti

Christopher A Hunter

Affiliations

Soon will be listed here.

Abstract

The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in "ideal" responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.

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