The Biology of Physiological Health

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2020 Apr 18

PMID 32302569

Citations 33

Authors

Janelle S Ayres

Affiliations

Soon will be listed here.

Abstract

The ability to maintain health, or recover to a healthy state after disease, is an active process involving distinct adaptation mechanisms coordinating interactions between all physiological systems of an organism. Studies over the past several decades have assumed the mechanisms of health and disease are essentially inter-changeable, focusing on the elucidation of the mechanisms of disease pathogenesis to enhance health, treat disease, and increase healthspan. Here, I propose that the evolved mechanisms of health are distinct from disease pathogenesis mechanisms and suggest that we develop an understanding of the biology of physiological health. In this Perspective, I provide a definition of, a conceptual framework for, and proposed mechanisms of physiological health to complement our understanding of disease and its treatment.

Citing Articles

Fluoxetine promotes IL-10-dependent metabolic defenses to protect from sepsis-induced lethality.

Gallant R, Sanchez K, Joulia E, Snyder J, Metallo C, Ayres J Sci Adv. 2025; 11(7):eadu4034.

PMID: 39951524 PMC: 11827869. DOI: 10.1126/sciadv.adu4034.

Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features: a proof-of-concept study.

Wu Y, Zhang X, Sun L, Wu Q, Liu X, Deng Y Natl Sci Rev. 2025; 12(1):nwae425.

PMID: 39816947 PMC: 11734281. DOI: 10.1093/nsr/nwae425.

Perspectives on Microbiome Therapeutics in Infectious Diseases: A Comprehensive Approach Beyond Immunology and Microbiology.

Seo H, Kim S, Beck S, Song H Cells. 2024; 13(23).

PMID: 39682751 PMC: 11640688. DOI: 10.3390/cells13232003.

Implementing Twaddle Triad to Reach a New Framework for an Integrative and Innovative Medicine.

Costa D, Serra R J Multidiscip Healthc. 2024; 17:4907-4923.

PMID: 39474633 PMC: 11520915. DOI: 10.2147/JMDH.S491021.

Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression.

Mbiydzenyuy N, Qulu L Metab Brain Dis. 2024; 39(8):1613-1636.

PMID: 39083184 PMC: 11535056. DOI: 10.1007/s11011-024-01393-w.

References

Taner T, Iqbal C, Textor S, Stegall M, Ishitani M . Compensatory hypertrophy of the remaining kidney in medically complex living kidney donors over the long term. Transplantation. 2014; 99(3):555-9. DOI: 10.1097/TP.0000000000000356. View

Ayres J, Schneider D . Tolerance of infections. Annu Rev Immunol. 2012; 30:271-94. DOI: 10.1146/annurev-immunol-020711-075030. View

Cremer S . Social immunity in insects. Curr Biol. 2019; 29(11):R458-R463. DOI: 10.1016/j.cub.2019.03.035. View

Duerr R, Huang S, Miraliakbar H, Clark R, Chien K, ROSS Jr J . Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J Clin Invest. 1995; 95(2):619-27. PMC: 295527. DOI: 10.1172/JCI117706. View

Umberson D, Montez J . Social relationships and health: a flashpoint for health policy. J Health Soc Behav. 2010; 51 Suppl:S54-66. PMC: 3150158. DOI: 10.1177/0022146510383501. View

Ayres J . Inflammasome-microbiota interplay in host physiologies. Cell Host Microbe. 2013; 14(5):491-7. DOI: 10.1016/j.chom.2013.10.013. View

Pavlov V, Tracey K . The vagus nerve and the inflammatory reflex--linking immunity and metabolism. Nat Rev Endocrinol. 2012; 8(12):743-54. PMC: 4082307. DOI: 10.1038/nrendo.2012.189. View

Schneider D . Tracing personalized health curves during infections. PLoS Biol. 2011; 9(9):e1001158. PMC: 3176750. DOI: 10.1371/journal.pbio.1001158. View

Raberg L, Graham A, Read A . Decomposing health: tolerance and resistance to parasites in animals. Philos Trans R Soc Lond B Biol Sci. 2008; 364(1513):37-49. PMC: 2666700. DOI: 10.1098/rstb.2008.0184. View

10.

Krause E, de Kloet A, Flak J, Smeltzer M, Solomon M, Evanson N . Hydration state controls stress responsiveness and social behavior. J Neurosci. 2011; 31(14):5470-6. PMC: 3086063. DOI: 10.1523/JNEUROSCI.6078-10.2011. View

11.

Metivier F, Marchais S, Guerin A, Pannier B, London G . Pathophysiology of anaemia: focus on the heart and blood vessels. Nephrol Dial Transplant. 2000; 15 Suppl 3:14-8. DOI: 10.1093/oxfordjournals.ndt.a027970. View

12.

Sanchez K, Chen G, Schieber A, Redford S, Shokhirev M, Leblanc M . Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen. Cell. 2018; 175(1):146-158.e15. PMC: 6447043. DOI: 10.1016/j.cell.2018.07.016. View

13.

Murray M, Murray A . Anorexia of infection as a mechanism of host defense. Am J Clin Nutr. 1979; 32(3):593-6. DOI: 10.1093/ajcn/32.3.593. View

14.

Seixas E, Gozzelino R, Chora A, Ferreira A, Silva G, Larsen R . Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc Natl Acad Sci U S A. 2009; 106(37):15837-42. PMC: 2728109. DOI: 10.1073/pnas.0903419106. View

15.

Castellano G, Affuso F, Di Conza P, Fazio S . The GH/IGF-1 Axis and Heart Failure. Curr Cardiol Rev. 2010; 5(3):203-15. PMC: 2822143. DOI: 10.2174/157340309788970306. View

16.

Corbett S, Courtiol A, Lummaa V, Moorad J, Stearns S . The transition to modernity and chronic disease: mismatch and natural selection. Nat Rev Genet. 2018; 19(7):419-430. DOI: 10.1038/s41576-018-0012-3. View

17.

Koshiyama H . Explanation of the insulin paradox from the evolutionary point of view. Jpn Clin Med. 2013; 3:21-4. PMC: 3738554. DOI: 10.4137/JCM.S10274. View

18.

Ayres J . Microbes Dress for Success: Tolerance or Resistance?. Trends Microbiol. 2016; 25(1):1-3. DOI: 10.1016/j.tim.2016.11.006. View

19.

Hoetzel A, Dolinay T, Schmidt R, Choi A, Ryter S . Carbon monoxide in sepsis. Antioxid Redox Signal. 2007; 9(11):2013-26. DOI: 10.1089/ars.2007.1762. View

20.

Louie A, Song K, Hotson A, Tate A, Schneider D . How Many Parameters Does It Take to Describe Disease Tolerance?. PLoS Biol. 2016; 14(4):e1002435. PMC: 4835111. DOI: 10.1371/journal.pbio.1002435. View