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Advances in Treatment Strategies for COVID-19: Insights from Other Coronavirus Diseases and Prospects

Overview
Journal Biosaf Health
Date 2025 Mar 13
PMID 40078910
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Abstract

The coronavirus disease 2019 (COVID-19) pandemic is the third human disease outbreak caused by an emerging coronavirus in the 21st century. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the COVID-19 pandemic has been the most devastating, with millions of deaths. Medical countermeasures are needed to limit the number of infections and fatalities. Here, we discuss advances in clinical and research-based treatment methods for SARS-CoV-2 that were initially derived from treatments for other coronaviruses. Recent advances in SARS-CoV-2 treatments, from traditional drugs and immunotherapies to artificial intelligence to predict potential future treatment methods, are summarized and discussed.

References
1.
Sun L, Xu K, Huang W, Yang Y, Li P, Tang L . Predicting dynamic cellular protein-RNA interactions by deep learning using in vivo RNA structures. Cell Res. 2021; 31(5):495-516. PMC: 7900654. DOI: 10.1038/s41422-021-00476-y. View

2.
Broughton J, Deng X, Yu G, Fasching C, Servellita V, Singh J . CRISPR-Cas12-based detection of SARS-CoV-2. Nat Biotechnol. 2020; 38(7):870-874. PMC: 9107629. DOI: 10.1038/s41587-020-0513-4. View

3.
Strohbehn G, Heiss B, Rouhani S, Trujillo J, Yu J, Kacew A . COVIDOSE: A Phase II Clinical Trial of Low-Dose Tocilizumab in the Treatment of Noncritical COVID-19 Pneumonia. Clin Pharmacol Ther. 2020; 109(3):688-696. PMC: 7753375. DOI: 10.1002/cpt.2117. View

4.
Tian W, Zhang N, Jin R, Feng Y, Wang S, Gao S . Immune suppression in the early stage of COVID-19 disease. Nat Commun. 2020; 11(1):5859. PMC: 7673112. DOI: 10.1038/s41467-020-19706-9. View

5.
Walz L, Cohen A, Rebaza A, Vanchieri J, Slade M, Dela Cruz C . JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysis. BMC Infect Dis. 2021; 21(1):47. PMC: 7797881. DOI: 10.1186/s12879-020-05730-z. View