Vitamin K2 Needs an RDI Separate from Vitamin K1

Overview

Journal Nutrients

Date 2020 Jun 25

PMID 32575901

Citations 34

Authors

Asim Cengiz Akbulut

Angelina Pavlic

Ploingarm Petsophonsakul

Maurice Halder

Katarzyna Maresz

Rafael Kramann

Leon Schurgers

Affiliations

Soon will be listed here.

Abstract

Vitamin K and its essential role in coagulation (vitamin K [Koagulation]) have been well established and accepted the world over. Many countries have a Recommended Daily Intake (RDI) for vitamin K based on early research, and its necessary role in the activation of vitamin K-dependent coagulation proteins is known. In the past few decades, the role of vitamin K-dependent proteins in processes beyond coagulation has been discovered. Various isoforms of vitamin K have been identified, and vitamin K2 specifically has been highlighted for its long half-life and extrahepatic activity, whereas the dietary form vitamin K1 has a shorter half-life. In this review, we highlight the specific activity of vitamin K2 based upon proposed frameworks necessary for a bioactive substance to be recommended for an RDI. Vitamin K2 meets all these criteria and should be considered for a specific dietary recommendation intake.

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