Tuning of Feedforward Control Enables Stable Muscle Force-length Dynamics After Loss of Autogenic Proprioceptive Feedback

Overview

Journal Elife

Specialty Biology

Date 2020 Jun 24

PMID 32573432

Citations 19

Authors

Joanne C Gordon

Natalie C Holt

Andrew Biewener

Monica A Daley

Affiliations

Soon will be listed here.

Abstract

Animals must integrate feedforward, feedback and intrinsic mechanical control mechanisms to maintain stable locomotion. Recent studies of guinea fowl () revealed that the distal leg muscles rapidly modulate force and work output to minimize perturbations in uneven terrain. Here we probe the role of reflexes in the rapid perturbation responses of muscle by studying the effects of proprioceptive loss. We induced bilateral loss of autogenic proprioception in the lateral gastrocnemius muscle (LG) using self-reinnervation. We compared in vivo muscle dynamics and ankle kinematics in birds with reinnervated and intact LG. Reinnervated and intact LG exhibit similar steady state mechanical function and similar work modulation in response to obstacle encounters. Reinnervated LG exhibits 23ms earlier steady-state activation, consistent with feedforward tuning of activation phase to compensate for lost proprioception. Modulation of activity duration is impaired in rLG, confirming the role of reflex feedback in regulating force duration in intact muscle.

Citing Articles

Investigating in vivo force and work production of rat medial gastrocnemius at varying locomotor speeds using a muscle avatar.

Bemis C, Konow N, Daley M, Nishikawa K J Exp Biol. 2024; 227(22).

PMID: 39445492 PMC: 11586523. DOI: 10.1242/jeb.248177.

The importance of muscle activation on the interpretation of muscle mechanical performance.

Kissane R, Askew G J Exp Biol. 2024; 227(21).

PMID: 39369302 PMC: 11574351. DOI: 10.1242/jeb.248051.

Linking in vivo muscle dynamics to force-length and force-velocity properties reveals that guinea fowl lateral gastrocnemius operates at shorter than optimal lengths.

Schwaner M, Mayfield D, Azizi E, Daley M J Exp Biol. 2024; 227(15).

PMID: 38873800 PMC: 11418180. DOI: 10.1242/jeb.246879.

Application of a feedforward control-based intervention for preventing hypothermia in trauma patients in a pre-hospital emergency setting.

Xu T, Jiang Y, Zhou G, Wu C Am J Transl Res. 2024; 16(4):1155-1164.

PMID: 38715835 PMC: 11070347. DOI: 10.62347/IRMG4893.

Mechanosensory encoding of forces in walking uphill and downhill: force feedback can stabilize leg movements in stick insects.

Zill S, Dallmann C, Zyhowski W, Chaudhry H, Gebehart C, Szczecinski N J Neurophysiol. 2024; 131(2):198-215.

PMID: 38166479 PMC: 11286306. DOI: 10.1152/jn.00414.2023.

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