Peripherally Induced Brain Tissue-resident Memory CD8 T Cells Mediate Protection Against CNS Infection

Overview

Journal Nat Immunol

Date 2020 Jun 24

PMID 32572242

Citations 60

Authors

Stina L Urban

Isaac J Jensen

Qiang Shan

Lecia L Pewe

Hai-Hui Xue

Vladimir P Badovinac

John T Harty

Affiliations

Soon will be listed here.

Abstract

The central nervous system (CNS) is classically viewed as immune-privileged; however, recent advances highlight interactions between the peripheral immune system and CNS in controlling infections and tissue homeostasis. Tissue-resident memory (T) CD8 T cells in the CNS are generated after brain infections, but it is unknown whether CNS infection is required to generate brain T cells. We show that peripheral infections generate antigen-specific CD8 memory T cells in the brain that adopt a unique T signature. Upon depletion of circulating and perivascular memory T cells, this brain signature was enriched and the surveilling properties of brain T cells was revealed by intravital imaging. Notably, peripherally induced brain T cells showed evidence of rapid activation and enhanced cytokine production and mediated protection after brain infections. These data reveal that peripheral immunizations can generate brain T cells and will guide potential use of T cells as therapeutic strategies against CNS infections and neurological diseases.

Citing Articles

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