New Advances in CNS Immunity Against Viral Infection

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2018 Jan 1

PMID 29289900

Citations 21

Authors

Monica Manglani

Dorian B McGavern

Affiliations

Soon will be listed here.

Abstract

The central nervous system (CNS) is an immunologically specialized organ where restrictive barrier structures protect the parenchyma from inflammation and infection. This protection is important in preventing damage to non-renewable resident cell populations, such as neurons, responsible for functions ranging from executive to autonomic. Despite these barriers, the CNS can be infected through several entry portals, giving rise to meningitis and encephalitis. Following infection, resident cells recruit peripherally derived immune cells to sites of viral infection. In this review, we discuss recent advances in immune recruitment and entry at barrier structures as well as current immunotherapeutic strategies for the treatment of persistent viral infections.

Citing Articles

Inflammatory and neuropathological responses to encephalitis in adult mice: variability, tolerance and resistance.

Cavalcante M, Santos D, Araujo L, Freitas P, Silva C, Carvalho K Front Cell Infect Microbiol. 2025; 15:1499658.

PMID: 40078875 PMC: 11897020. DOI: 10.3389/fcimb.2025.1499658.

Why do central nervous system barriers host a diverse immune landscape?.

Zanluqui N, McGavern D Trends Immunol. 2024; 45(10):738-749.

PMID: 39299888 PMC: 11471389. DOI: 10.1016/j.it.2024.08.009.

The Impact of Innate Components on Viral Pathogenesis in the Neurotropic Coronavirus Encephalomyelitis Mouse Model.

Boylan B, Hwang M, Bergmann C Viruses. 2023; 15(12).

PMID: 38140641 PMC: 10747027. DOI: 10.3390/v15122400.

Antiviral response within different cell types of the CNS.

Telikani Z, Monson E, Hofer M, Helbig K Front Immunol. 2022; 13:1044721.

PMID: 36458002 PMC: 9706196. DOI: 10.3389/fimmu.2022.1044721.

B cells going viral in the CNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis.

Cardani-Boulton A, Boylan B, Stetsenko V, Bergmann C Immunol Rev. 2022; 311(1):75-89.

PMID: 35984298 PMC: 9804320. DOI: 10.1111/imr.13124.

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