Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Dec 18

PMID 30555489

Citations 48

Authors

Karin Steinbach

Ilena Vincenti

Doron Merkler

Affiliations

Soon will be listed here.

Abstract

Tissue-resident-memory CD8+ T cells (T) have been described as a non-circulating memory T cell subset that persists at sites of previous infection. While T in all non-lymphoid organs probably share a core signature differentiation pathway, certain aspects of their maintenance and effector functions may vary. It is well-established that T provide long-lived protective immunity through immediate effector function and accelerated recruitment of circulating immune cells. Besides immune defense against pathogens, other immunological roles of T are less well-studied. Likewise, evidence of a putative detrimental role of T for inflammatory diseases is only beginning to emerge. In this review, we discuss the protective and harmful role of T in organ-specific immunity and immunopathology as well as prospective implications for immunomodulatory therapy.

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