Natural Products, PGC-1 , and Duchenne Muscular Dystrophy

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2020 Jun 13

PMID 32528825

Citations 33

Authors

Ipek Suntar

Antoni Sureda

Tarun Belwal

Ana Sanches Silva

Rosa Anna Vacca

Devesh Tewari

Eduardo Sobarzo-Sanchez

Seyed Fazel Nabavi

Samira Shirooie

Ahmad Reza Dehpour

Suowen Xu

Bahman Yousefi

Maryam Majidinia

Maria Daglia

Giuseppe DAntona

Seyed Mohammad Nabavi

Affiliations

Soon will be listed here.

Abstract

Peroxisome proliferator-activated receptor (PPAR) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPAR coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues, and play a key part in the regulation of the oxidative metabolism, consequently modulating the production of reactive oxygen species, autophagy, and mitochondrial biogenesis. Owing to these findings, a large body of studies, aiming to establish the role of PGC-1 in the neuromuscular system, has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases. Among these, some evidence has shown that various signaling pathways linked to PGC-1 are deregulated in muscular dystrophy, leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species (ROS) production. In the light of these results, any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies. PGC-1 is influenced by different patho-physiological/pharmacological stimuli. Natural products have been reported to display modulatory effects on PPAR activation with fewer side effects in comparison to synthetic drugs. Taken together, this review summarizes the current knowledge on Duchenne muscular dystrophy, focusing on the potential effects of natural compounds, acting as regulators of PGC-1.

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