Mitochondria: a Breakthrough in Combating Rheumatoid Arthritis

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2024 Aug 20

PMID 39161412

Authors

Shuang Li

Chenlu Huo

Anting Liu

Yan Zhu

Affiliations

Soon will be listed here.

Abstract

As a chronic autoimmune disease with complex aetiology, rheumatoid arthritis (RA) has been demonstrated to be associated with mitochondrial dysfunction since mitochondrial dysfunction can affect the survival, activation, and differentiation of immune and non-immune cells involved in the pathogenesis of RA. Nevertheless, the mechanism behind mitochondrial dysfunction in RA remains uncertain. Accordingly, this review addresses the possible role and mechanisms of mitochondrial dysfunction in RA and discusses the potential and challenges of mitochondria as a potential therapeutic strategy for RA, thereby providing a breakthrough point in the prevention and treatment of RA.

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