Hypothalamic Tanycytes Generate Acute Hyperphagia Through Activation of the Arcuate Neuronal Network

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2020 Jun 10

PMID 32513737

Citations 23

Authors

Matei Bolborea

Eric Pollatzek

Heather Benford

Tamara Sotelo-Hitschfeld

Nicholas Dale

Affiliations

Soon will be listed here.

Abstract

Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. To test whether they can activate neurons of the arcuate nucleus, we targeted expression of a Ca-permeable channelrhodopsin (CatCh) specifically to tanycytes. Activation of tanycytes ex vivo depolarized orexigenic (neuropeptide Y/agouti-related protein; NPY/AgRP) and anorexigenic (proopiomelanocortin; POMC) neurons via an ATP-dependent mechanism. In vivo, activation of tanycytes triggered acute hyperphagia only in the fed state during the inactive phase of the light-dark cycle.

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