The Prevalence of Occult HBV Infection in Immunized Children with HBsAg-positive Parents: a Hospital-based Analysis

Overview

Journal Hepatol Int

Publisher Springer

Specialty Gastroenterology

Date 2020 May 31

PMID 32472310

Citations 5

Authors

Shurui Zhuge

Congcong Ge

Yuting Yang

Yuxia Cui

Xiaomei Yue

Zhenzhen Zhang

Hongmei Xu

Ailong Huang

Yao Zhao

Affiliations

Soon will be listed here.

Abstract

Background And Object: The risk of occult HBV infection (OBI) in children whose mothers are HBV carriers has received more widespread attention, but there were few reports to focus on the children with HBsAg-positive parents. In this study, we aimed to investigate the prevalence of OBI in immunized children with HBsAg-positive parents.

Methods: HBV-vaccinated Chinese hospitalized children with HBsAg-positive parents were analyzed in our investigation. Eligible subjects were tested using a standard nested PCR for all HBV genes, and analyzed by direct sequencing.

Results: There were 327 HBsAg-negative children included in the study out of about 9800 involved HBV-vaccinated hospitalized children. The positive rate of OBI was 3.1% (10/327) in the eligible children and 14.1% (46/327) with HBV DNA detectable. No significant differences were found between one and at least two regions positive groups (p > 0.05). The proportions of HBV DNA detectable in children with HBV father-carriers and mother-carriers were similar. The risk factors for HBV DNA-positive children could be male, anti-HBs levels, and anti-HBc positive.

Conclusion: There are 3.1% of OBIs and 14.1% of suspected OBI in vaccinated children with HBsAg-positive parents. The potential risk of suspected OBI in children with HBsAg-positive father should not be ignored. Anti-HBc positivity may be a useful seromarker for suspected OBI screening in vaccinated children. To prevent HBV breakthrough infection, accurate and convenient method is needed to detect OBI timely and exhaustively.

Citing Articles

An overview of occult hepatitis B infection (OBI) with emphasis on HBV vaccination.

Delghandi S, Raoufinia R, Shahtahmasbi S, Meshkat Z, Gouklani H, Gholoobi A Heliyon. 2024; 10(17):e37097.

PMID: 39281486 PMC: 11402251. DOI: 10.1016/j.heliyon.2024.e37097.

The Characteristic of HBV Quasispecies Is Related to Occult HBV Infection of Infants Born to Highly Viremic Mothers.

Li Y, Song Y, Xiao Y, Wang T, Li L, Liu M Viruses. 2024; 16(7).

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Decreased placental TLR3 is associated with hepatitis B virus vaccine responsiveness in infants born to HBsAg-positive mothers.

Wu L, Fu G, Xu X, Yi L, Yao T, Wan H Transl Pediatr. 2023; 12(6):1204-1212.

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Booster Vaccination in Infancy Reduces the Incidence of Occult HBV Infection in Maternal HBsAg-positive Children.

Li Y, Li L, Song Y, Liu M, Zhai X, Duan Z J Clin Transl Hepatol. 2023; 11(3):661-669.

PMID: 36969892 PMC: 10037503. DOI: 10.14218/JCTH.2022.00213.

Anti-HBc-nonreactive occult hepatitis B infections with HBV genotypes B and C in vaccinated immunocompetent adults.

Deng X, Guo X, Gu H, Wang D, Laperche S, Allain J J Viral Hepat. 2022; 29(11):958-967.

PMID: 35876456 PMC: 9804389. DOI: 10.1111/jvh.13733.

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