Detection and Sequence Analysis of Hepatitis B Virus Integration in Peripheral Blood Mononuclear Cells

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1999 Jan 9

PMID 9882326

Citations 18

Authors

T Laskus

M Radkowski

L F Wang

M Nowicki

J Rakela

Affiliations

Soon will be listed here.

Abstract

A PCR-based technique was used to detect hepatitis B virus (HBV) integration in peripheral blood mononuclear cells from patients with chronic hepatitis B. Integrated HBV DNA sequences, with virus-cell junctions located in the cohesive region between direct repeat 1 (DR1) and DR2, were found in 2 of 10 studied patients.

Citing Articles

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Integration of Viral Genome to Human Genomic DNA in Nails of Patients with Chronic Hepatitis B Virus Infection.

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Hepatitis B virus DNA integration as a novel biomarker of hepatitis B virus-mediated pathogenetic properties and a barrier to the current strategies for hepatitis B virus cure.

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