Human Pluripotent Stem Cell-derived Cardiac Stromal Cells and Their Applications in Regenerative Medicine

Overview

Journal Stem Cell Res

Publisher Elsevier

Specialty Cell Biology

Date 2020 May 24

PMID 32446219

Citations 5

Authors

Martha E Floy

Taylor D Mateyka

Koji L Foreman

Sean P Palecek

Affiliations

Soon will be listed here.

Abstract

Coronary heart disease is one of the leading causes of death in the United States. Recent advances in stem cell biology have led to the development and engineering of human pluripotent stem cell (hPSC)-derived cardiac cells and tissues for application in cellular therapy and cardiotoxicity studies. Initial studies in this area have largely focused on improving differentiation efficiency and maturation states of cardiomyocytes. However, other cell types in the heart, including endothelial and stromal cells, play crucial roles in cardiac development, injury response, and cardiomyocyte function. This review discusses recent advances in differentiation of hPSCs to cardiac stromal cells, identification and classification of cardiac stromal cell types, and application of hPSC-derived cardiac stromal cells and tissues containing these cells in regenerative and drug development applications.

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