A Transcriptomic and Epigenomic Comparison of Fetal and Adult Human Cardiac Fibroblasts Reveals Novel Key Transcription Factors in Adult Cardiac Fibroblasts

Overview

Journal JACC Basic Transl Sci

Date 2018 Sep 1

PMID 30167544

Citations 24

Authors

Malin K B Jonsson

Robin J G Hartman

Matthew Ackers-Johnson

Wilson L W Tan

Bing Lim

Toon A B van Veen

Roger S Foo

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease remains the number one global cause of death and presents as multiple phenotypes in which the interplay between cardiomyocytes and cardiac fibroblasts (CFs) has become increasingly highlighted. Fetal and adult CFs influence neighboring cardiomyocytes in different ways. Thus far, a detailed comparison between the two is lacking. Using a genome-wide approach, we identified and validated 2 crucial players for maintaining the adult primary human CF phenotype. Knockdown of these factors induced significant phenotypical changes, including senescence and reduced collagen gene expression. These may now represent novel therapeutic targets against deleterious functions of CFs in adult cardiovascular disease.

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