Differential Diagnosis of Plasma Cell Mastitis and Invasive Ductal Carcinoma Using Multiparametric MRI

Overview

Journal Gland Surg

Publisher AME Publishing Company

Specialty Endocrinology

Date 2020 May 19

PMID 32420252

Citations 4

Authors

Rong Chen

Baoquan Hu

Yulong Zhang

Caibao Liu

Lianhua Zhao

Yan Jiang

Yan Xu

Affiliations

Soon will be listed here.

Abstract

Background: Evaluate the potential of multiparametric magnetic resonance imaging (MRI) for the differential diagnosis of plasma cell mastitis (PCM) and invasive ductal carcinoma (IDC).

Methods: A total of 465 female patients, including 197 PCM (42.4%) and 268 IDC (57.6%), were examined using breast MRI scanning using routine sequences, dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted imaging (DWI) and MR spectroscopy (MRS). The MRI features of PCM and IDC lesions were analyzed and compared to the histological results.

Results: Compared to IDC, the PCM lesions were more frequent in the subareolar regions, hyperintense on T2WI (P<0.01) and showed an initial signal increase ≤90%, a persistent and plateau pattern of time-intensity curves, non-mass enhancement, multiple rim enhancements, central hyperintensity on DWI, a higher ADC value, and total choline (tCho) peak negative and tCho peak integral <29.95 AU (P<0.01). The following breast-associated findings were also observed frequently in PCM: Ipsilateral breast enlargement, nipple retraction, skin thickening, peripheral edema and axillary lymphadenopathy. However, no significant difference was observed between the two groups for the shape, border and adjacent vessel signs of the lesion.

Conclusions: Some of the MRI features of PCM and IDC lesions were different. An integrated analysis of these multiparametric MRI features can thus assist in the differential diagnosis of PCM and IDC lesions.

Citing Articles

Bilateral plasma cell mastitis simulating breast cancer: a case report and literature review.

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Incidental Finding of Invasive Ductal Carcinoma on Mastectomy in the Case of Lymphocytic Mastitis: A Case Report.

Bahadure S, Noman O, Jaiswal N, Bandre G, Akulwar A Cureus. 2023; 15(9):e44545.

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Combining contrast-enhanced ultrasound and blood cell analysis to improve diagnostic accuracy of plasma cell mastitis.

Zheng Y, Wang L, Han X, Shen L, Ling C, Qian Z Exp Biol Med (Maywood). 2021; 247(2):97-105.

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Chinese herbal compound combined with western medicine therapy in the treatment of plasma cell mastitis: A protocol for systematic review and meta-analysis.

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