Determinants of Survival After Forebrain Ischemia in Mongolian Gerbils

Overview

Journal Metab Brain Dis

Publisher Springer

Specialties Endocrinology
Neurology

Date 1988 Dec 1

PMID 3241602

Citations 1

Authors

K Weber

A Baethmann

O Kempski

Affiliations

Soon will be listed here.

Abstract

Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia.

Citing Articles

Effect of P-selectin inhibition on leukocyte-endothelium interaction and survival after global cerebral ischemia.

Lehmberg J, Beck J, Baethmann A, Uhl E J Neurol. 2005; 253(3):357-63.

PMID: 16215846 DOI: 10.1007/s00415-005-0996-4.

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