"Time is Spine": the Importance of Early Intervention for Traumatic Spinal Cord Injury

Overview

Journal Spinal Cord

Specialty Neurology

Date 2020 May 13

PMID 32393795

Citations 27

Authors

Christopher S Ahuja

Jetan H Badhiwala

Michael G Fehlings

Affiliations

Soon will be listed here.

Citing Articles

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Effects of Teriparatide and Alendronate on Functional Recovery from Spinal Cord Injury and Postinjury Bone Loss.

Wang S, Zhu J, Feng Y, Hua Y, You G, Su J Biomedicines. 2025; 13(2).

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Total and Free Zinc Dynamics as Biomarkers for Neurological Impairment in Traumatic Spinal Cord Injury.

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Anterior cervical discectomy and fusion for subaxial cervical spine injuries; management challenges and early outcome in a neurosurgical center.

Campbell F, Ndukuba K, Ndubuisi C, Okwunodulu O, Mezue W, Ohaegbulam S Surg Neurol Int. 2025; 16:17.

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Recombinant Acidic Fibroblast Growth Factor Facilitates Motor Recovery and Reduces Myelomalacia in Traumatic American Spinal Injury Association Impairment Scale A Spinal Cord Injured Patients.

Chang W, Huang W, Tsai Y, Yang L, Su Y, Huang S Neurotrauma Rep. 2024; 5(1):910-915.

PMID: 39440148 PMC: 11491575. DOI: 10.1089/neur.2024.0063.

References

Fehlings M, Vaccaro A, Wilson J, Singh A, Cadotte D, Harrop J . Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS One. 2012; 7(2):e32037. PMC: 3285644. DOI: 10.1371/journal.pone.0032037. View

Tator C, Fehlings M, Thorpe K, Taylor W . Current use and timing of spinal surgery for management of acute spinal surgery for management of acute spinal cord injury in North America: results of a retrospective multicenter study. J Neurosurg. 1999; 91(1 Suppl):12-8. DOI: 10.3171/spi.1999.91.1.0012. View

Batchelor P, Wills T, Skeers P, Battistuzzo C, Macleod M, Howells D . Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure. PLoS One. 2013; 8(8):e72659. PMC: 3751840. DOI: 10.1371/journal.pone.0072659. View

Ahuja C, Wilson J, Nori S, Kotter M, Druschel C, Curt A . Traumatic spinal cord injury. Nat Rev Dis Primers. 2017; 3:17018. DOI: 10.1038/nrdp.2017.18. View

Fehlings M, Rabin D, Sears W, Cadotte D, Aarabi B . Current practice in the timing of surgical intervention in spinal cord injury. Spine (Phila Pa 1976). 2010; 35(21 Suppl):S166-73. DOI: 10.1097/BRS.0b013e3181f386f6. View

Furlan J, Noonan V, Cadotte D, Fehlings M . Timing of decompressive surgery of spinal cord after traumatic spinal cord injury: an evidence-based examination of pre-clinical and clinical studies. J Neurotrauma. 2009; 28(8):1371-99. PMC: 3143409. DOI: 10.1089/neu.2009.1147. View

Hachem L, Ahuja C, Fehlings M . Assessment and management of acute spinal cord injury: From point of injury to rehabilitation. J Spinal Cord Med. 2017; 40(6):665-675. PMC: 5778930. DOI: 10.1080/10790268.2017.1329076. View

Glennie R, Bailey C, Tsai E, Noonan V, Rivers C, Fourney D . An analysis of ideal and actual time to surgery after traumatic spinal cord injury in Canada. Spinal Cord. 2017; 55(6):618-623. DOI: 10.1038/sc.2016.177. View

Dimar 2nd J, Glassman S, Raque G, Zhang Y, Shields C . The influence of spinal canal narrowing and timing of decompression on neurologic recovery after spinal cord contusion in a rat model. Spine (Phila Pa 1976). 1999; 24(16):1623-33. DOI: 10.1097/00007632-199908150-00002. View

10.

Wilson J, Tetreault L, Kwon B, Arnold P, Mroz T, Shaffrey C . Timing of Decompression in Patients With Acute Spinal Cord Injury: A Systematic Review. Global Spine J. 2017; 7(3 Suppl):95S-115S. PMC: 5684838. DOI: 10.1177/2192568217701716. View

11.

Fehlings M, Wilson J . Timing of surgical intervention in spinal trauma: what does the evidence indicate?. Spine (Phila Pa 1976). 2010; 35(21 Suppl):S159-60. DOI: 10.1097/BRS.0b013e3181f330f4. View

12.

Anderson K, Tetreault L, Shamji M, Singh A, Vukas R, Harrop J . Optimal Timing of Surgical Decompression for Acute Traumatic Central Cord Syndrome: A Systematic Review of the Literature. Neurosurgery. 2015; 77 Suppl 4:S15-32. DOI: 10.1227/NEU.0000000000000946. View

13.

Jug M, Kejzar N, Vesel M, Al Mawed S, Dobravec M, Herman S . Neurological Recovery after Traumatic Cervical Spinal Cord Injury Is Superior if Surgical Decompression and Instrumented Fusion Are Performed within 8 Hours versus 8 to 24 Hours after Injury: A Single Center Experience. J Neurotrauma. 2015; 32(18):1385-92. DOI: 10.1089/neu.2014.3767. View

14.

Badhiwala J, Ahuja C, Fehlings M . Time is spine: a review of translational advances in spinal cord injury. J Neurosurg Spine. 2019; 30(1):1-18. DOI: 10.3171/2018.9.SPINE18682. View

15.

Burke J, Yue J, Ngwenya L, Winkler E, Talbott J, Pan J . Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury. Neurosurgery. 2018; 85(2):199-203. DOI: 10.1093/neuros/nyy537. View

16.

Fehlings M, Tetreault L, Wilson J, Aarabi B, Anderson P, Arnold P . A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury and Central Cord Syndrome: Recommendations on the Timing (≤24 Hours Versus >24 Hours) of Decompressive Surgery. Global Spine J. 2017; 7(3 Suppl):195S-202S. PMC: 5684850. DOI: 10.1177/2192568217706367. View