Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: Studies

Overview

Journal Front Pharmacol

Date 2020 May 12

PMID 32390824

Citations 17

Authors

Ludmilla R Jorge

Liliam K Harada

Erica C Silva

Welida F Campos

Fernanda C Moreli

Gustavo Shimamoto

Jorge F B Pereira

Jose M Oliveira Jr

Matthieu Tubino

Marta M D C Vila

Victor M Balcao

Affiliations

Soon will be listed here.

Abstract

In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin.

Citing Articles

The Design Features, Quality by Design Approach, Characterization, Therapeutic Applications, and Clinical Considerations of Transdermal Drug Delivery Systems-A Comprehensive Review.

Sivadasan D, Madkhali O Pharmaceuticals (Basel). 2024; 17(10).

PMID: 39458987 PMC: 11510585. DOI: 10.3390/ph17101346.

Topical Administration of an Apoptosis Inducer Mitigates Bleomycin-Induced Skin Fibrosis.

Huda M, Borrego E, Guerena C, Varela-Ramirez A, Aguilera R, Hamadani C ACS Pharmacol Transl Sci. 2023; 6(5):829-841.

PMID: 37200808 PMC: 10186622. DOI: 10.1021/acsptsci.3c00039.

Recent Development of Nanomaterials for Transdermal Drug Delivery.

Leong M, Kong Y, Burgess K, Wong W, Sethi G, Looi C Biomedicines. 2023; 11(4).

PMID: 37189742 PMC: 10136181. DOI: 10.3390/biomedicines11041124.

Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release.

Dumitriu Buzia O, Paduraru A, Stefan C, Dinu M, Cocos D, Nwabudike L Pharmaceutics. 2023; 15(4).

PMID: 37111667 PMC: 10143057. DOI: 10.3390/pharmaceutics15041183.

Recent Advancement of Medical Patch for Transdermal Drug Delivery.

Wong W, Ang K, Sethi G, Looi C Medicina (Kaunas). 2023; 59(4).

PMID: 37109736 PMC: 10142343. DOI: 10.3390/medicina59040778.

References

Jung E, Maibach H . Animal models for percutaneous absorption. J Appl Toxicol. 2014; 35(1):1-10. DOI: 10.1002/jat.3004. View

Petersen N, Gatenholm P . Bacterial cellulose-based materials and medical devices: current state and perspectives. Appl Microbiol Biotechnol. 2011; 91(5):1277-86. DOI: 10.1007/s00253-011-3432-y. View

Chan A, Mauro T . Acidification in the epidermis and the role of secretory phospholipases. Dermatoendocrinol. 2011; 3(2):84-90. PMC: 3117007. DOI: 10.4161/derm.3.2.15140. View

Salerno C, Carlucci A, Bregni C . Study of in vitro drug release and percutaneous absorption of fluconazole from topical dosage forms. AAPS PharmSciTech. 2010; 11(2):986-93. PMC: 2902339. DOI: 10.1208/s12249-010-9457-1. View

Zakrewsky M, Lovejoy K, Kern T, Miller T, Le V, Nagy A . Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization. Proc Natl Acad Sci U S A. 2014; 111(37):13313-8. PMC: 4169946. DOI: 10.1073/pnas.1403995111. View

Rajwade J, Paknikar K, Kumbhar J . Applications of bacterial cellulose and its composites in biomedicine. Appl Microbiol Biotechnol. 2015; 99(6):2491-511. DOI: 10.1007/s00253-015-6426-3. View

Balcao V, Vieira M, Malcata F . Adsorption of protein from several commercial lipase preparations onto a hollow-fiber membrane module. Biotechnol Prog. 1996; 12(2):164-72. DOI: 10.1021/bp950070n. View

Seabra A, Pasquoto T, Ferrarini A, Santos M, Haddad P, De Lima R . Preparation, characterization, cytotoxicity, and genotoxicity evaluations of thiolated- and s-nitrosated superparamagnetic iron oxide nanoparticles: implications for cancer treatment. Chem Res Toxicol. 2014; 27(7):1207-18. DOI: 10.1021/tx500113u. View

Todo H . Transdermal Permeation of Drugs in Various Animal Species. Pharmaceutics. 2017; 9(3). PMC: 5620574. DOI: 10.3390/pharmaceutics9030033. View

10.

Baker M, Walsh S, Schwartz Z, Boyan B . A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. J Biomed Mater Res B Appl Biomater. 2012; 100(5):1451-7. DOI: 10.1002/jbm.b.32694. View

11.

Lee S, Jeong S, Ahn S . An update of the defensive barrier function of skin. Yonsei Med J. 2006; 47(3):293-306. PMC: 2688147. DOI: 10.3349/ymj.2006.47.3.293. View

12.

Li Y, Quan Y, Zang L, Jin M, Kamiyama F, Katsumi H . Transdermal delivery of insulin using trypsin as a biochemical enhancer. Biol Pharm Bull. 2008; 31(8):1574-9. DOI: 10.1248/bpb.31.1574. View

13.

Elias P . Stratum corneum defensive functions: an integrated view. J Invest Dermatol. 2005; 125(2):183-200. DOI: 10.1111/j.0022-202X.2005.23668.x. View

14.

Dandurand J, Samouillan V, Lacoste-Ferre M, Lacabanne C, Bochicchio B, Pepe A . Conformational and thermal characterization of a synthetic peptidic fragment inspired from human tropoelastin: Signature of the amyloid fibers. Pathol Biol (Paris). 2014; 62(2):100-7. DOI: 10.1016/j.patbio.2014.02.001. View

15.

Boateng J, Matthews K, Stevens H, Eccleston G . Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2007; 97(8):2892-923. DOI: 10.1002/jps.21210. View

16.

Khafagy E, Morishita M, Onuki Y, Takayama K . Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev. 2007; 59(15):1521-46. DOI: 10.1016/j.addr.2007.08.019. View

17.

Lassmann-Vague V, Raccah D . Alternatives routes of insulin delivery. Diabetes Metab. 2006; 32(5 Pt 2):513-22. DOI: 10.1016/s1262-3636(06)72804-x. View