The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Nov 13

PMID 34769430

Citations 13

Authors

Ana Gomes

Luisa Aguiar

Ricardo Ferraz

Catia Teixeira

Paula Gomes

Affiliations

Soon will be listed here.

Abstract

Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.

Citing Articles

Design Principles and Applications of Ionic Liquids for Transdermal Drug Delivery.

Gao S, Cheng X, Zhang M, Dai Q, Liu C, Lu Y Adv Sci (Weinh). 2024; 11(43):e2405983.

PMID: 39342651 PMC: 11578336. DOI: 10.1002/advs.202405983.

Choline-based ionic liquids enhance the dermal delivery of cyclosporine a for potential treatment of psoriasis.

Li Y, Yu Q, Lu Y, Ma Y, Qi J, Chen Z Drug Deliv Transl Res. 2024; .

PMID: 39237671 DOI: 10.1007/s13346-024-01705-8.

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges.

Chen X, Li Z, Yang C, Yang D Asian J Pharm Sci. 2024; 19(2):100900.

PMID: 38590797 PMC: 10999516. DOI: 10.1016/j.ajps.2024.100900.

The Development and Characterization of Novel Ionic Liquids Based on Mono- and Dicarboxylates with Meglumine for Drug Solubilizers and Skin Permeation Enhancers.

Furuishi T, Taguchi S, Wang S, Fukuzawa K, Yonemochi E Pharmaceutics. 2024; 16(3).

PMID: 38543216 PMC: 10974018. DOI: 10.3390/pharmaceutics16030322.

Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing.

Zhao L, Chen J, Bai B, Song G, Zhang J, Yu H Front Pharmacol. 2024; 14:1333986.

PMID: 38293666 PMC: 10825035. DOI: 10.3389/fphar.2023.1333986.

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