Transdermal Permeation Assays of Curcumin Aided by CAGE-IL: In Vivo Control of Psoriasis

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2022 Apr 23

PMID 35456612

Authors

Rodrigo Boscariol

Erika A Caetano

Denise Grotto

Raquel M Rosa-Castro

Jose M Oliveira Junior

Marta M D C Vila

Victor M Balcao

Affiliations

Soon will be listed here.

Abstract

Psoriasis is a clinically heterogeneous skin disease with an important genetic component, whose pathophysiology is not yet fully understood and for which there is still no cure. Hence, alternative therapies have been evaluated, using plant species such as turmeric ( Linn.) in topical preparations. However, the stratum corneum is a barrier to be overcome, and ionic liquids have emerged as potential substances that promote skin permeation. Thus, the main objective of this research was to evaluate a biopolysaccharide hydrogel formulation integrating curcumin with choline and geranic acid ionic liquid (CAGE-IL) as a facilitator of skin transdermal permeation, in the treatment of chemically induced psoriasis in mice. The developed gel containing curcumin and CAGE-IL showed a high potential for applications in the treatment of psoriasis, reversing the histological manifestations of psoriasis to a state very close to that of normal skin.

Citing Articles

Hyaluronidase Promote Transdermal Diffusion of Small Sized Curcumin Nanocrystal by Dissolving Microneedles Delivery.

Miao X, Zhao J, Xiang H, Shi X Pharmaceutics. 2023; 15(3).

PMID: 36986649 PMC: 10056829. DOI: 10.3390/pharmaceutics15030788.

References

Zhang X, He Y . The Role of Nociceptive Neurons in the Pathogenesis of Psoriasis. Front Immunol. 2020; 11:1984. PMC: 7550422. DOI: 10.3389/fimmu.2020.01984. View

Smarr B, Grant A, Zucker I, Prendergast B, Kriegsfeld L . Sex differences in variability across timescales in BALB/c mice. Biol Sex Differ. 2017; 8:7. PMC: 5301430. DOI: 10.1186/s13293-016-0125-3. View

Silva E, Oliveira T, Moreli F, Harada L, Vila M, Balcao V . Newly isolated lytic bacteriophages for Staphylococcus intermedius, structurally and functionally stabilized in a hydroxyethylcellulose gel containing choline geranate: Potential for transdermal permeation in veterinary phage therapy. Res Vet Sci. 2021; 135:42-58. DOI: 10.1016/j.rvsc.2020.12.013. View

Zhang Y, Xia Q, Li Y, He Z, Li Z, Guo T . CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin. Theranostics. 2019; 9(1):48-64. PMC: 6332788. DOI: 10.7150/thno.29715. View

Wu S, Cho E, Li W, Grodstein F, Qureshi A . Hormonal Factors and Risk of Psoriasis in Women: A Cohort Study. Acta Derm Venereol. 2015; 96(7):927-931. DOI: 10.2340/00015555-2312. View

Swindell W, Michaels K, Sutter A, Diaconu D, Fritz Y, Xing X . Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis. Genome Med. 2017; 9(1):24. PMC: 5345243. DOI: 10.1186/s13073-017-0415-3. View

Nguyen L, Ahn S, Nguyen U, Yang I . Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production. Phytomedicine. 2018; 47:48-57. DOI: 10.1016/j.phymed.2018.04.051. View

Dionisio M, Grenha A . Locust bean gum: Exploring its potential for biopharmaceutical applications. J Pharm Bioallied Sci. 2012; 4(3):175-85. PMC: 3425165. DOI: 10.4103/0975-7406.99013. View

Li Q, Liu W, Gao S, Mao Y, Xin Y . Application of imiquimod-induced murine psoriasis model in evaluating interleukin-17A antagonist. BMC Immunol. 2021; 22(1):11. PMC: 7844923. DOI: 10.1186/s12865-021-00401-3. View

10.

Raut G, Wairkar S . Management of psoriasis with nutraceuticals: An update. Complement Ther Clin Pract. 2018; 31:25-30. DOI: 10.1016/j.ctcp.2018.01.007. View

11.

Varma S, Sivaprakasam T, Mishra A, Prabhu S, M R, P R . Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin. Eur J Pharmacol. 2017; 813:33-41. DOI: 10.1016/j.ejphar.2017.07.040. View

12.

Filippone A, Consoli G, Granata G, Casili G, Lanza M, Ardizzone A . Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model. Int J Mol Sci. 2020; 21(14). PMC: 7404063. DOI: 10.3390/ijms21145053. View

13.

Gendrisch F, Haarhaus B, Krieger N, Quirin K, Schempp C, Wolfle U . The Effect of Herbal Medicinal Products on Psoriasis-Like Keratinocytes. Biomolecules. 2021; 11(3). PMC: 8000521. DOI: 10.3390/biom11030371. View

14.

Alturkistani H, Tashkandi F, Mohammedsaleh Z . Histological Stains: A Literature Review and Case Study. Glob J Health Sci. 2015; 8(3):72-9. PMC: 4804027. DOI: 10.5539/gjhs.v8n3p72. View

15.

Zhang R, Zhang Z, McClements D . Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods. Colloids Surf B Biointerfaces. 2020; 194:111202. DOI: 10.1016/j.colsurfb.2020.111202. View

16.

Todke P, Shah V . Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches. Int J Dermatol. 2018; 57(11):1387-1402. DOI: 10.1111/ijd.14047. View

17.

Mudgil D, Barak S, Khatkar B . Guar gum: processing, properties and food applications-A Review. J Food Sci Technol. 2014; 51(3):409-18. PMC: 3931889. DOI: 10.1007/s13197-011-0522-x. View

18.

Sun L, Liu Z, Wang L, Cun D, Tong H, Yan R . Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel. J Control Release. 2017; 254:44-54. DOI: 10.1016/j.jconrel.2017.03.385. View

19.

Shakeri A, Cicero A, Panahi Y, Mohajeri M, Sahebkar A . Curcumin: A naturally occurring autophagy modulator. J Cell Physiol. 2018; 234(5):5643-5654. DOI: 10.1002/jcp.27404. View

20.

Sun L, Liu Z, Lin Z, Cun D, Tong H, Yan R . Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles. Int J Nanomedicine. 2018; 13:5625-5635. PMC: 6154705. DOI: 10.2147/IJN.S170832. View