Heartbeat OCE: Corneal Biomechanical Response to Simulated Heartbeat Pulsation Measured by Optical Coherence Elastography

Overview

Journal J Biomed Opt

Specialties Biomedical Engineering
Ophthalmology

Date 2020 May 7

PMID 32372574

Citations 17

Authors

Achuth Nair

Manmohan Singh

Salavat R Aglyamov

Kirill V Larin

Affiliations

Soon will be listed here.

Abstract

Significance: It is generally agreed that the corneal mechanical properties are strongly linked to many eye diseases and could be used to assess disease progression and response to therapies. Elastography is the most notable method of assessing corneal mechanical properties, but it generally requires some type of external excitation to induce a measurable displacement in the tissue.

Aim: We present Heartbeat Optical Coherence Elastography (Hb-OCE), a truly passive method that can measure the elasticity of the cornea based on intrinsic corneal displacements induced by the heartbeat.

Approach: Hb-OCE measurements were performed in untreated and UV-A/riboflavin cross-linked porcine corneas ex vivo, and a distinct difference in strain was detected. Furthermore, a partially cross-linked cornea was also assessed, and the treated and untreated areas were similarly distinguished.

Results: Our results suggest that Hb-OCE can spatially map displacements in the cornea induced by small fluctuations in intraocular pressure, similar to what is induced by the heartbeat.

Conclusions: The described technique opens the possibility for completely passive and noncontact in vivo assessment of corneal stiffness.

Citing Articles

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Acute alcohol consumption modulates corneal biomechanical properties as revealed by optical coherence elastography.

Mekonnen T, Zevallos-Delgado C, Hatami M, Singh M, Aglyamov S, Larin K J Biomech. 2024; 169:112155.

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Full-field noise-correlation elastography for in-plane mechanical anisotropy imaging.

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Optical coherence elastography measures the biomechanical properties of the porcine cornea after LASIK.

Nair A, Zvietcovich F, Singh M, Weikert M, Aglyamov S, Larin K J Biomed Opt. 2024; 29(1):016002.

PMID: 38223300 PMC: 10787573. DOI: 10.1117/1.JBO.29.1.016002.

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Singh M, Nair A, Aglyamov S, Larin K Photonics. 2023; 8(4).

PMID: 37727230 PMC: 10508915. DOI: 10.3390/photonics8040111.

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