Preventing Cytokine Storm Syndrome in COVID-19 Using α-1 Adrenergic Receptor Antagonists

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2020 May 1

PMID 32352407

Citations 70

Authors

Maximilian F Konig

Mike Powell

Verena Staedtke

Ren-Yuan Bai

David L Thomas

Nicole Fischer

Sakibul Huq

Adham M Khalafallah

Allison Koenecke

Ruoxuan Xiong

Brett Mensh

Nickolas Papadopoulos

Kenneth W Kinzler

Bert Vogelstein

Joshua T Vogelstein

Susan Athey

Shibin Zhou

Chetan Bettegowda

Affiliations

Soon will be listed here.

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References

Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H . Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020; 130(5):2620-2629. PMC: 7190990. DOI: 10.1172/JCI137244. View

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C . Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4):420-422. PMC: 7164771. DOI: 10.1016/S2213-2600(20)30076-X. View

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z . Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395(10229):1054-1062. PMC: 7270627. DOI: 10.1016/S0140-6736(20)30566-3. View

Ruan Q, Yang K, Wang W, Jiang L, Song J . Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020; 46(5):846-848. PMC: 7080116. DOI: 10.1007/s00134-020-05991-x. View

Pedersen S, Ho Y . SARS-CoV-2: a storm is raging. J Clin Invest. 2020; 130(5):2202-2205. PMC: 7190904. DOI: 10.1172/JCI137647. View

Channappanavar R, Perlman S . Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017; 39(5):529-539. PMC: 7079893. DOI: 10.1007/s00281-017-0629-x. View

Xu X, Han M, Li T, Sun W, Wang D, Fu B . Effective treatment of severe COVID-19 patients with tocilizumab. Proc Natl Acad Sci U S A. 2020; 117(20):10970-10975. PMC: 7245089. DOI: 10.1073/pnas.2005615117. View

Staedtke V, Bai R, Kim K, Darvas M, Davila M, Riggins G . Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome. Nature. 2018; 564(7735):273-277. PMC: 6512810. DOI: 10.1038/s41586-018-0774-y. View

Mehta P, McAuley D, Brown M, Sanchez E, Tattersall R, Manson J . COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020; 395(10229):1033-1034. PMC: 7270045. DOI: 10.1016/S0140-6736(20)30628-0. View

10.

Zheng Y, Ma Y, Zhang J, Xie X . COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020; 17(5):259-260. PMC: 7095524. DOI: 10.1038/s41569-020-0360-5. View

11.

Luo P, Liu Y, Qiu L, Liu X, Liu D, Li J . Tocilizumab treatment in COVID-19: A single center experience. J Med Virol. 2020; 92(7):814-818. PMC: 7262125. DOI: 10.1002/jmv.25801. View

12.

Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y . Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020; 71(15):762-768. PMC: 7108125. DOI: 10.1093/cid/ciaa248. View

13.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223):497-506. PMC: 7159299. DOI: 10.1016/S0140-6736(20)30183-5. View

14.

McGonagle D, Sharif K, ORegan A, Bridgewood C . The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease. Autoimmun Rev. 2020; 19(6):102537. PMC: 7195002. DOI: 10.1016/j.autrev.2020.102537. View