Association Analysis of the HNF4A Common Genetic Variants with Type 2 Diabetes Mellitus Risk

Overview

Journal Int J Mol Cell Med

Specialty Genetics

Date 2020 May 1

PMID 32351910

Citations 9

Authors

Seyedeh Mina Azizi

Negar Sarhangi

Mahdi Afshari

Davood Abbasi

Hamid Reza Aghaei Meybodi

Mandana Hasanzad

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes mellitus (T2DM) is a complex disease that involves a wide range of genetic and environmental factors. The carries out hepatic gluconeogenesis regulation and insulin secretion crucially, and the corresponding gene was shown to be linked to T2DM in several studies. The aim of the present study was to evaluate the association between genetic variants (rs1884613 and rs1884614) and T2DM risk in a group of Iranian patients. This case-control study included 100 patients with T2DM and 100 control subjects. Genotyping of two single nucleotide polymorphisms (SNPs) (rs1884613 and rs1884614) of was performed using the sequencing method. There was no statistically significant difference for allele and genotype distribution of the common variants (rs1884613 and rs1884614) between subjects with and without T2DM (P=0.9 and P=0.9, respectively). Regarding diabetic complications, although the presence of mentioned polymorphisms increased the odds of developing ophthalmic complications and reduction of the odds of renal complications among diabetic patients, the mentioned risk was non- significant and cannot be generalized to the whole population. It seems that rs1884613 and rs1884614 polymorphisms are not associated with T2DM or its renal and ophthalmic complications. To investigate the precise influence of these polymorphisms, prospective cohorts with larger sample sizes are required.

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