Meta-analysis of Genome-wide Association Studies Identifies Eight New Loci for Type 2 Diabetes in East Asians

Overview

Journal Nat Genet

Specialty Genetics

Date 2011 Dec 14

PMID 22158537

Citations 344

Authors

Yoon Shin Cho

Chien-Hsiun Chen

Cheng Hu

Jirong Long

Rick Twee Hee Ong

Xueling Sim

Fumihiko Takeuchi

Ying Wu

Min Jin Go

Toshimasa Yamauchi

Yi-Cheng Chang

Soo Heon Kwak

Ronald C W Ma

Ken Yamamoto

Linda S Adair

Tin Aung

Qiuyin Cai

Li-Ching Chang

Yuan-Tsong Chen

Yutang Gao

Frank B Hu

Hyung-Lae Kim

Sangsoo Kim

Young Jin Kim

Jeannette Jen-Mai Lee

Nanette R Lee

Yun Li

Jian Jun Liu

Wei Lu

Jiro Nakamura

Eitaro Nakashima

Daniel Peng-Keat Ng

Wan Ting Tay

Fuu-Jen Tsai

Tien Yin Wong

Mitsuhiro Yokota

Wei Zheng

Rong Zhang

Congrong Wang

Wing Yee So

Keizo Ohnaka

Hiroshi Ikegami

Kazuo Hara

Young Min Cho

Nam H Cho

Tien-Jyun Chang

Yuqian Bao

Asa K Hedman

Andrew P Morris

Mark I McCarthy

Ryoichi Takayanagi

Kyong Soo Park

Weiping Jia

Lee-Ming Chuang

Juliana C N Chan

Shiro Maeda

Takashi Kadowaki

Jong-Young Lee

Jer-Yuarn Wu

Yik Ying Teo

E Shyong Tai

Xiao Ou Shu

Karen L Mohlke

Norihiro Kato

Bok-Ghee Han

Mark Seielstad

Affiliations

Soon will be listed here.

Abstract

We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.

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