The Phylogenetic Landscape and Nosocomial Spread of the Multidrug-resistant Opportunist Stenotrophomonas Maltophilia

Overview

Journal Nat Commun

Specialty Biology

Date 2020 Apr 29

PMID 32341346

Citations 53

Authors

Matthias I Groschel

Conor J Meehan

Ivan Barilar

Margo Diricks

Aitor Gonzaga

Matthias Steglich

Oscar Conchillo-Sole

Isabell-Christin Scherer

Uwe Mamat

Christian F Luz

Katrien De Bruyne

Christian Utpatel

Daniel Yero

Isidre Gibert

Xavier Daura

Stefanie Kampmeier

Nurdyana Abdul Rahman

Michael Kresken

Tjip S van der Werf

Ifey Alio

Wolfgang R Streit

Kai Zhou

Thomas Schwartz

John W A Rossen

Maha R Farhat

Ulrich E Schaible

Ulrich Nubel

Jan Rupp

Joerg Steinmann

Stefan Niemann

Thomas A Kohl

Affiliations

Soon will be listed here.

Abstract

Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.

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