Stenotrophomonas Maltophilia: an Emerging Global Opportunistic Pathogen

Overview

Journal Clin Microbiol Rev

Publisher American Society for Microbiology

Specialty Microbiology

Date 2012 Jan 11

PMID 22232370

Citations 565

Authors

Joanna S Brooke

Affiliations

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Abstract

Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia can occur in a range of organs and tissues; the organism is commonly found in respiratory tract infections. This review summarizes the current literature and presents S. maltophilia as an organism with various molecular mechanisms used for colonization and infection. S. maltophilia can be recovered from polymicrobial infections, most notably from the respiratory tract of cystic fibrosis patients, as a cocolonizer with Pseudomonas aeruginosa. Recent evidence of cell-cell communication between these pathogens has implications for the development of novel pharmacological therapies. Animal models of S. maltophilia infection have provided useful information about the type of host immune response induced by this opportunistic pathogen. Current and emerging treatments for patients infected with S. maltophilia are discussed.

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References

Masgala A, Galani I, Souli M, Giamarellou H . Discrepancies between various methods in susceptibility testing and epidemiological analysis of Stenotrophomonas maltophilia clinical isolates. Cent Eur J Public Health. 2010; 18(2):119-23. DOI: 10.21101/cejph.a3571. View

Berney M, Hammes F, Bosshard F, Weilenmann H, Egli T . Assessment and interpretation of bacterial viability by using the LIVE/DEAD BacLight Kit in combination with flow cytometry. Appl Environ Microbiol. 2007; 73(10):3283-90. PMC: 1907116. DOI: 10.1128/AEM.02750-06. View

Calza L, Manfredi R, Chiodo F . Stenotrophomonas (Xanthomonas) maltophilia as an emerging opportunistic pathogen in association with HIV infection: a 10-year surveillance study. Infection. 2003; 31(3):155-61. DOI: 10.1007/s15010-003-3113-6. View

Avison M, von Heldreich C, Higgins C, Bennett P, Walsh T . A TEM-2beta-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia. J Antimicrob Chemother. 2000; 46(6):879-84. DOI: 10.1093/jac/46.6.879. View

Collis C, Kim M, Stokes H, Hall R . Binding of the purified integron DNA integrase Intl1 to integron- and cassette-associated recombination sites. Mol Microbiol. 1998; 29(2):477-90. DOI: 10.1046/j.1365-2958.1998.00936.x. View

Adjide C, De Meyer A, Weyer M, Obin O, Lamory F, Lesueur C . [A sensitive, specific and predictive isolation medium developed for Stenotrophomonas maltophilia study in healthcare settings]. Pathol Biol (Paris). 2009; 58(1):11-7. DOI: 10.1016/j.patbio.2009.07.004. View

Kolodkin-Gal I, Romero D, Cao S, Clardy J, Kolter R, Losick R . D-amino acids trigger biofilm disassembly. Science. 2010; 328(5978):627-9. PMC: 2921573. DOI: 10.1126/science.1188628. View

Nakamura A, Sugimoto Y, Ohishi K, Sugawara Y, Fujieda A, Monma F . Diagnostic value of PCR analysis of bacteria and fungi from blood in empiric-therapy-resistant febrile neutropenia. J Clin Microbiol. 2010; 48(6):2030-6. PMC: 2884527. DOI: 10.1128/JCM.01700-09. View

Bonfield T, Panuska J, Konstan M, Hilliard K, Hilliard J, Ghnaim H . Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med. 1995; 152(6 Pt 1):2111-8. DOI: 10.1164/ajrccm.152.6.8520783. View

10.

Mancini D, Mendonca R, Dias A, Mendonca R, Pinto J . Co-infection between influenza virus and flagellated bacteria. Rev Inst Med Trop Sao Paulo. 2005; 47(5):275-80. DOI: 10.1590/s0036-46652005000500007. View

11.

Al-Jasser A . Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: an increasing problem. Ann Clin Microbiol Antimicrob. 2006; 5:23. PMC: 1578578. DOI: 10.1186/1476-0711-5-23. View

12.

Marchac V, Equi A, Le Bihan-Benjamin C, Hodson M, Bush A . Case-control study of Stenotrophomonas maltophilia acquisition in cystic fibrosis patients. Eur Respir J. 2004; 23(1):98-102. DOI: 10.1183/09031936.03.00007203. View

13.

Gutierrez Rodero F, Masia M, Cortes J, Ortiz de la Tabla V, Mainar V, Vilar A . Endocarditis caused by Stenotrophomonas maltophilia: case report and review. Clin Infect Dis. 1996; 23(6):1261-5. DOI: 10.1093/clinids/23.6.1261. View

14.

Lee P, Tullman-Ercek D, Georgiou G . The bacterial twin-arginine translocation pathway. Annu Rev Microbiol. 2006; 60:373-95. PMC: 2654714. DOI: 10.1146/annurev.micro.60.080805.142212. View

15.

Al Naiemi N, Duim B, Bart A . A CTX-M extended-spectrum beta-lactamase in Pseudomonas aeruginosa and Stenotrophomonas maltophilia. J Med Microbiol. 2006; 55(Pt 11):1607-1608. DOI: 10.1099/jmm.0.46704-0. View

16.

Rojas P, Garcia E, Calderon G, Ferreira F, Rosso M . Successful treatment of Stenotrophomonas maltophilia meningitis in a preterm baby boy: a case report. J Med Case Rep. 2009; 3:7389. PMC: 2737774. DOI: 10.4076/1752-1947-3-7389. View

17.

Adjide C, De Meyer A, Weyer M, Obin O, Lamory F, Lesueur C . [Stenotrophomonas maltophilia and Pseudomonas aeruginosa water-associated microbiologic risk assessment in Amiens' University Hospital Centre]. Pathol Biol (Paris). 2009; 58(2):e1-5. DOI: 10.1016/j.patbio.2009.07.006. View

18.

Chang L, Chen H, Chang C, Lee T, Wu W . Contribution of integrons, and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother. 2004; 53(3):518-21. DOI: 10.1093/jac/dkh094. View

19.

Donlan R . Preventing biofilms of clinically relevant organisms using bacteriophage. Trends Microbiol. 2009; 17(2):66-72. DOI: 10.1016/j.tim.2008.11.002. View

20.

Palleroni N, BRADBURY J . Stenotrophomonas, a new bacterial genus for Xanthomonas maltophilia (Hugh 1980) Swings et al. 1983. Int J Syst Bacteriol. 1993; 43(3):606-9. DOI: 10.1099/00207713-43-3-606. View