Reciprocal Regulation Between Alternative Splicing and the DNA Damage Response

Overview

Journal Genet Mol Biol

Specialty Genetics

Date 2020 Apr 3

PMID 32236390

Citations 2

Authors

Adrian E Cambindo Botto

Juan C Munoz

Luciana E Giono

Nicolas Nieto-Moreno

Carmen Cuenca

Alberto R Kornblihtt

Manuel J Munoz

Affiliations

Soon will be listed here.

Abstract

Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transcriptome. Since 95% of the human coding genome is subjected to alternative splicing regulation, it is expected that many cellular pathways are modulated by alternative splicing, as is the case for the DNA damage response. Moreover, recent evidence demonstrates that upon a genotoxic insult, classical DNA damage response kinases such as ATM, ATR and DNA-PK orchestrate the gene expression response therefore modulating alternative splicing which, in a reciprocal way, shapes the response to a damaging agent.

Citing Articles

Maturation State-Specific Alternative Splicing in -ITD and NPM1 Mutated AML.

Wojtuszkiewicz A, van der Werf I, Hutter S, Walter W, Baer C, Kern W Cancers (Basel). 2021; 13(16).

PMID: 34439083 PMC: 8394193. DOI: 10.3390/cancers13163929.

Splicing alterations in healthy aging and disease.

Angarola B, Anczukow O Wiley Interdiscip Rev RNA. 2021; 12(4):e1643.

PMID: 33565261 PMC: 8195850. DOI: 10.1002/wrna.1643.

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