Defining Trained Immunity and Its Role in Health and Disease

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2020 Mar 6

PMID 32132681

Citations 998

Authors

Mihai G Netea

Jorge Dominguez-Andres

Luis B Barreiro

Triantafyllos Chavakis

Maziar Divangahi

Elaine Fuchs

Leo A B Joosten

Jos W M van der Meer

Musa M Mhlanga

Willem J M Mulder

Niels P Riksen

Andreas Schlitzer

Joachim L Schultze

Christine Stabell Benn

Joseph C Sun

Ramnik J Xavier

Eicke Latz

Affiliations

Soon will be listed here.

Abstract

Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

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