Trained Immunity: A Program of Innate Immune Memory in Health and Disease

Overview

Journal Science

Specialty Science

Date 2016 Apr 23

PMID 27102489

Citations 1139

Authors

Mihai G Netea

Leo A B Joosten

Eicke Latz

Kingston H G Mills

Gioacchino Natoli

Hendrik G Stunnenberg

Luke A J ONeill

Ramnik J Xavier

Affiliations

Soon will be listed here.

Abstract

The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in mammals, the innate immune system can mount resistance to reinfection, a phenomenon termed "trained immunity" or "innate immune memory." Trained immunity is orchestrated by epigenetic reprogramming, broadly defined as sustained changes in gene expression and cell physiology that do not involve permanent genetic changes such as mutations and recombination, which are essential for adaptive immunity. The discovery of trained immunity may open the door for novel vaccine approaches, new therapeutic strategies for the treatment of immune deficiency states, and modulation of exaggerated inflammation in autoinflammatory diseases.

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