Joachim L Schultze
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Explore the profile of Joachim L Schultze including associated specialties, affiliations and a list of published articles.
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271
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20494
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Recent Articles
1.
Ehlers G, Todtmann A, Holsten L, Willers M, Heckmann J, Schoning J, et al.
Nat Commun
. 2025 Mar;
16(1):2239.
PMID: 40050264
Neonates primarily rely on innate immune defense, yet their inflammatory responses are usually restricted compared to adults. This is controversially interpreted as a sign of immaturity or essential programming, increasing...
2.
Oestreich M, Merdivan E, Lee M, Schultze J, Piraud M, Becker M
J Cheminform
. 2025 Feb;
17(1):23.
PMID: 40001177
With the cost/yield-ratio of drug development becoming increasingly unfavourable, recent work has explored machine learning to accelerate early stages of the development process. Given the current success of deep generative...
3.
Bresser M, Siemens K, Schneider L, Lunnebach J, Leven P, Glowka T, et al.
EMBO Mol Med
. 2025 Jan;
17(2):301-335.
PMID: 39762650
Current studies pictured the enteric nervous system and macrophages as modulators of neuroimmune processes in the inflamed gut. Expanding this view, we investigated the impact of enteric neuron-macrophage interactions on...
4.
Schmidt A, Casadei N, Brand F, Demidov G, Vojgani E, Abolhassani A, et al.
PLoS Pathog
. 2024 Dec;
20(12):e1012786.
PMID: 39715278
Courses of SARS-CoV-2 infections are highly variable, ranging from asymptomatic to lethal COVID-19. Though research has shown that host genetic factors contribute to this variability, cohort-based joint analyses of variants...
5.
Kroger C, Muller S, Leidner J, Krober T, Warnat-Herresthal S, Spintge J, et al.
Nat Commun
. 2024 Dec;
15(1):10702.
PMID: 39702306
High-dimensional cytometry (HDC) is a powerful technology for studying single-cell phenotypes in complex biological systems. Although technological developments and affordability have made HDC broadly available in recent years, technological advances...
6.
Wischhof L, Lee H, Tutas J, Overkott C, Tedt E, Stork M, et al.
EMBO J
. 2024 Sep;
43(19):4437-4438.
PMID: 39223333
No abstract available.
7.
Shirvani O, Warnat-Herresthal S, Savchuk I, Bode F, Nitsch L, Stosser S, et al.
Ann Clin Transl Neurol
. 2024 Aug;
11(10):2696-2706.
PMID: 39180278
Objective: Predicting long-term functional outcomes shortly after a stroke is challenging, even for experienced neurologists. Therefore, we aimed to evaluate multiple machine learning models and the importance of clinical/radiological parameters...
8.
Knoll R, Helbig E, Dahm K, Bolaji O, Hamm F, Dietrich O, et al.
Cell
. 2024 Jul;
187(16):4318-4335.e20.
PMID: 38964327
Dexamethasone is a life-saving treatment for severe COVID-19, yet its mechanism of action is unknown, and many patients deteriorate or die despite timely treatment initiation. Here, we identify dexamethasone treatment-induced...
9.
Carraro C, Montgomery J, Klimmt J, Paquet D, Schultze J, Beyer M
Front Mol Neurosci
. 2024 Jul;
17:1414886.
PMID: 38952421
Drug discovery is a generally inefficient and capital-intensive process. For neurodegenerative diseases (NDDs), the development of novel therapeutics is particularly urgent considering the long list of late-stage drug candidate failures....
10.
Boos J, van der Made C, Ramakrishnan G, Coughlan E, Asselta R, Loscher B, et al.
HGG Adv
. 2024 Jun;
5(4):100323.
PMID: 38944683
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52...