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Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases

Overview
Journal Noncoding RNA
Date 2020 Feb 26
PMID 32093161
Citations 18
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Abstract

Nuclear bodies are membraneless, phase-separated compartments that concentrate specific proteins and RNAs in the nucleus. They are believed to serve as sites for the modification, sequestration, and storage of specific factors, and to act as organizational hubs of chromatin structure to control gene expression and cellular function. Architectural (arc) RNA, a class of long noncoding RNA (lncRNA), plays essential roles in the formation of nuclear bodies. Herein, we focus on specific arcRNAs containing short tandem repeat-enriched sequences and introduce their biological functions and recently elucidated underlying molecular mechanism. In various neurodegenerative diseases, abnormal nuclear and cytoplasmic bodies are built on disease-causing RNAs or toxic RNAs with aberrantly expanded short tandem repeat-enriched sequences. We discuss the possible analogous functions of natural arcRNAs and toxic RNAs with short tandem repeat-enriched sequences. Finally, we describe the technical utility of short tandem repeat-enriched arcRNAs as a model for exploring the structures and functions of nuclear bodies, as well as the pathogenic mechanisms of neurodegenerative diseases.

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References
1.
Denegri M, Moralli D, Rocchi M, Biggiogera M, Raimondi E, Cobianchi F . Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies. Mol Biol Cell. 2002; 13(6):2069-79. PMC: 117625. DOI: 10.1091/mbc.01-12-0569. View

2.
Valgardsdottir R, Chiodi I, Giordano M, Rossi A, Bazzini S, Ghigna C . Transcription of Satellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res. 2007; 36(2):423-34. PMC: 2241877. DOI: 10.1093/nar/gkm1056. View

3.
Zu T, Gibbens B, Doty N, Gomes-Pereira M, Huguet A, Stone M . Non-ATG-initiated translation directed by microsatellite expansions. Proc Natl Acad Sci U S A. 2010; 108(1):260-5. PMC: 3017129. DOI: 10.1073/pnas.1013343108. View

4.
Kopp F, Elguindy M, Yalvac M, Zhang H, Chen B, Gillett F . PUMILIO hyperactivity drives premature aging of -deficient mice. Elife. 2019; 8. PMC: 6407921. DOI: 10.7554/eLife.42650. View

5.
Mannen T, Yamashita S, Tomita K, Goshima N, Hirose T . The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL. J Cell Biol. 2016; 214(1):45-59. PMC: 4932371. DOI: 10.1083/jcb.201601024. View