The Human Gastrointestinal Microbiota and Prostate Cancer Development and Treatment

Overview

Journal Investig Clin Urol

Specialty Urology

Date 2020 Feb 15

PMID 32055753

Citations 35

Authors

Sybil Sha

Liqiang Ni

Maria Stefil

Matthew Dixon

Vladimir Mouraviev

Affiliations

Soon will be listed here.

Abstract

The human gastrointestinal microbiome contains commensal bacteria and other microbiota that have been gaining increasing attention in the context of cancer development and response to treatment. Microbiota play a role in the maintenance of host barrier surfaces that contribute to both local inflammation and other systemic metabolic functions. In the context of prostate cancer, the gastrointestinal microbiome may play a role through metabolism of estrogen, an increase of which has been linked to the induction of prostatic neoplasia. Specific microbiota such as , , , , , and have been associated with differing risks of prostate cancer development or extensiveness of prostate cancer disease. In this Review, we discuss gastrointestinal microbiota's effects on prostate cancer development, the ability of the microbiome to regulate chemotherapy for prostate cancer treatment, and the importance of using Next Generation Sequencing to further discern the microbiome's systemic influence on prostate cancer.

Citing Articles

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