Burn Injury

Overview

Journal Nat Rev Dis Primers

Specialty General Medicine

Date 2020 Feb 15

PMID 32054846

Citations 359

Authors

Marc G Jeschke

Margriet E van Baar

Mashkoor A Choudhry

Kevin K Chung

Nicole S Gibran

Sarvesh Logsetty

Affiliations

Soon will be listed here.

Abstract

Burn injuries are under-appreciated injuries that are associated with substantial morbidity and mortality. Burn injuries, particularly severe burns, are accompanied by an immune and inflammatory response, metabolic changes and distributive shock that can be challenging to manage and can lead to multiple organ failure. Of great importance is that the injury affects not only the physical health, but also the mental health and quality of life of the patient. Accordingly, patients with burn injury cannot be considered recovered when the wounds have healed; instead, burn injury leads to long-term profound alterations that must be addressed to optimize quality of life. Burn care providers are, therefore, faced with a plethora of challenges including acute and critical care management, long-term care and rehabilitation. The aim of this Primer is not only to give an overview and update about burn care, but also to raise awareness of the ongoing challenges and stigmata associated with burn injuries.

Citing Articles

Profiling of miRNAs Contained in Circulating Extracellular Vesicles and Associated with Sepsis Development in Burn Patients: A Proof-of-Concept Study.

Schiavello M, Bosco O, Vizio B, Sciarrillo A, Pensa A, Pivetta E Int J Mol Sci. 2025; 26(5).

PMID: 40076471 PMC: 11899136. DOI: 10.3390/ijms26051844.

The effect of nicardipine on the zone of stasis in burns: An experimental rat model.

Deniz R, Igde M, Tan Baser N, Atilgan N, Yumusak N, Birtane N Ulus Travma Acil Cerrahi Derg. 2025; 31(3):207-213.

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Unlocking the role of wound microbiome in diabetic, burn, and germ-free wound repair treated by natural and synthetic scaffolds.

Xu Z, Zhang L, Tang Q, Yang C, Ding X, Wang Z Acta Pharm Sin B. 2025; 15(1):611-626.

PMID: 40041888 PMC: 11873655. DOI: 10.1016/j.apsb.2024.08.024.

Precision diagnosis of burn injuries using imaging and predictive modeling for clinical applications.

Rangaiah P, Kumar B, Huss F, Augustine R Sci Rep. 2025; 15(1):7604.

PMID: 40038450 PMC: 11880334. DOI: 10.1038/s41598-025-92096-4.

Activated Microglia Mediate the Motor Neuron-, Synaptic Denervation- and Muscle Wasting-Changes in Burn Injured Mice.

Chen J, Kitagawa Y, Xie F, Li H, Kem W, You Z J Cachexia Sarcopenia Muscle. 2025; 16(2):e13755.

PMID: 40035088 PMC: 11876847. DOI: 10.1002/jcsm.13755.

References

Wetta-Hall R, Jost J, Jost G, Praheswari Y, Berg-Copas G . Preparing for burn disasters: evaluation of a continuing education training course for pre-hospital and hospital professionals in Kansas. J Burn Care Res. 2007; 28(1):97-104. DOI: 10.1097/BCR.0B013E31802Cb815. View

Hakimi N, Cheng R, Leng L, Sotoudehfar M, Ba P, Bakhtyar N . Handheld skin printer: in situ formation of planar biomaterials and tissues. Lab Chip. 2018; 18(10):1440-1451. PMC: 5965293. DOI: 10.1039/c7lc01236e. View

Spiwak R, Logsetty S, Afifi T, Sareen J . Severe partner perpetrated burn: Examining a nationally representative sample of women in India. Burns. 2015; 41(8):1847-1854. DOI: 10.1016/j.burns.2015.08.035. View

Murphy P, Evans G . Advances in wound healing: a review of current wound healing products. Plast Surg Int. 2012; 2012:190436. PMC: 3335515. DOI: 10.1155/2012/190436. View

Nielson C, Duethman N, Howard J, Moncure M, Wood J . Burns: Pathophysiology of Systemic Complications and Current Management. J Burn Care Res. 2016; 38(1):e469-e481. PMC: 5214064. DOI: 10.1097/BCR.0000000000000355. View

Sanghavi P, Bhalla K, Das V . Fire-related deaths in India in 2001: a retrospective analysis of data. Lancet. 2009; 373(9671):1282-8. DOI: 10.1016/S0140-6736(09)60235-X. View

Mutlu E, Keshavarzian A, Engen P, Forsyth C, Sikaroodi M, Gillevet P . Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol Clin Exp Res. 2009; 33(10):1836-46. PMC: 3684271. DOI: 10.1111/j.1530-0277.2009.01022.x. View

Peck M, Molnar J, Swart D . A global plan for burn prevention and care. Bull World Health Organ. 2009; 87(10):802-3. PMC: 2755313. DOI: 10.2471/blt.08.059733. View

Rehberg S, Maybauer M, Enkhbaatar P, Maybauer D, Yamamoto Y, Traber D . Pathophysiology, management and treatment of smoke inhalation injury. Expert Rev Respir Med. 2010; 3(3):283-297. PMC: 2722076. DOI: 10.1586/ERS.09.21. View

10.

Kahn S, Patel J, Lentz C, Bell D . Firefighter burn injuries: predictable patterns influenced by turnout gear. J Burn Care Res. 2011; 33(1):152-6. DOI: 10.1097/BCR.0b013e318234d8d9. View

11.

Edgar D, Dawson A, Hankey G, Phillips M, Wood F . Demonstration of the validity of the SF-36 for measurement of the temporal recovery of quality of life outcomes in burns survivors. Burns. 2010; 36(7):1013-20. DOI: 10.1016/j.burns.2010.03.001. View

12.

Kool M, Geenen R, Egberts M, Wanders H, Van Loey N . Patients' perspectives on quality of life after burn. Burns. 2017; 43(4):747-756. DOI: 10.1016/j.burns.2016.11.016. View

13.

Kupper T, Green D, Durum S, Baker C . Defective antigen presentation to a cloned T helper cell by macrophages from burned mice can be restored with interleukin-1. Surgery. 1985; 98(2):199-206. View

14.

Gerlach J, Johnen C, McCoy E, Brautigam K, Plettig J, Corcos A . Autologous skin cell spray-transplantation for a deep dermal burn patient in an ambulant treatment room setting. Burns. 2011; 37(4):e19-23. DOI: 10.1016/j.burns.2011.01.022. View

15.

Greenhalgh D . Burn resuscitation: the results of the ISBI/ABA survey. Burns. 2009; 36(2):176-82. DOI: 10.1016/j.burns.2009.09.004. View

16.

Antonacci A, Calvano S, Reaves L, Prajapati A, Bockman R, Welte K . Autologous and allogeneic mixed-lymphocyte responses following thermal injury in man: the immunomodulatory effects of interleukin 1, interleukin 2, and a prostaglandin inhibitor, WY-18251. Clin Immunol Immunopathol. 1984; 30(2):304-20. DOI: 10.1016/0090-1229(84)90064-3. View

17.

Baker C, Miller C, Trunkey D . Predicting fatal sepsis in burn patients. J Trauma. 1979; 19(9):641-8. DOI: 10.1097/00005373-197909000-00001. View

18.

Torres L, Chung K, Salgado C, Dubick M, Torres Filho I . Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids. Crit Care. 2017; 21(1):160. PMC: 5490091. DOI: 10.1186/s13054-017-1745-7. View

19.

Schluter B, Konig W, Koller M, Erbs G, Muller F . Differential regulation of T- and B-lymphocyte activation in severely burned patients. J Trauma. 1991; 31(2):239-46. View

20.

Wasiak J, Lee S, Paul E, Shen A, Tan H, Cleland H . Female patients display poorer burn-specific quality of life 12 months after a burn injury. Injury. 2016; 48(1):87-93. DOI: 10.1016/j.injury.2016.07.032. View