Astrocytes and Microglia: In Sickness and in Health

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2020 Feb 12

PMID 32044129

Citations 212

Authors

Ilia D Vainchtein

Anna V Molofsky

Affiliations

Soon will be listed here.

Abstract

Healthy central nervous system (CNS) development and function require an intricate and balanced bidirectional communication between neurons and glia cells. In this review, we discuss the complementary roles of astrocytes and microglia in building the brain, including in the formation and refinement of synapses. We discuss recent evidence demonstrating how these interactions are coordinated in the transition from healthy physiology towards disease and discuss known and potential molecular mechanisms that mediate this cellular crosstalk.

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