Resident Memory B Cells

Overview

Journal Viral Immunol

Specialties Allergy & Immunology
Microbiology

Date 2020 Feb 6

PMID 32023188

Citations 38

Authors

S Rameeza Allie

Troy D Randall

Affiliations

Soon will be listed here.

Abstract

In mammals, adaptive immunity is mediated by a broadly diverse repertoire of naive B and T lymphocytes that recirculate between secondary lymphoid organs. Initial antigen exposure promotes lymphocyte clonal expansion and differentiation, including the formation of memory cells. Antigen-specific memory cells are maintained at higher frequencies than their naive counterparts and have different functional and homing abilities. Importantly, a subset of memory cells, known as tissue-resident memory cells, is maintained without recirculating in nonlymphoid tissues, often at barrier surfaces, where they can be reactivated by antigen and rapidly perform effector functions that help protect the tissue in which they reside. Although antigen-experienced B cells are abundant at many barrier surfaces, their characterization as tissue-resident memory B (BRM) cells is not well developed. In this study, we describe the characteristics of memory B cells in various locations and discuss their possible contributions to immunity and homeostasis as BRM cells.

Citing Articles

Viral Infection and Dissemination Through the Lymphatic System.

Brisse M, Hickman H Microorganisms. 2025; 13(2).

PMID: 40005808 PMC: 11858409. DOI: 10.3390/microorganisms13020443.

B cells in non-lymphoid tissues.

Samiea A, Celis G, Yadav R, Rodda L, Moreau J Nat Rev Immunol. 2025; .

PMID: 39910240 DOI: 10.1038/s41577-025-01137-6.

Lung-resident lymphocytes and their roles in respiratory infections and chronic respiratory diseases.

Sen Chaudhuri A, Sun J Chin Med J Pulm Crit Care Med. 2025; 2(4):214-223.

PMID: 39834580 PMC: 11742555. DOI: 10.1016/j.pccm.2024.11.006.

Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection.

Sircy L, Ramstead A, Gibbs L, Joshi H, Baessler A, Mena I PLoS Pathog. 2024; 20(9):e1011639.

PMID: 39283916 PMC: 11404825. DOI: 10.1371/journal.ppat.1011639.

Spatial immunophenotyping using multiplexed imaging of immune follicles in secondary lymphoid tissues.

Allam M, Hu T, Fang Z, Pi M, Singh A, Coskun A PNAS Nexus. 2024; 3(8):pgae285.

PMID: 39108301 PMC: 11299982. DOI: 10.1093/pnasnexus/pgae285.

References

Ridderstad A, Tarlinton D . Kinetics of establishing the memory B cell population as revealed by CD38 expression. J Immunol. 1998; 160(10):4688-95. View

Hazenberg M, Spits H . Human innate lymphoid cells. Blood. 2014; 124(5):700-9. DOI: 10.1182/blood-2013-11-427781. View

Linton P, Bautista B, Biederman E, Bradley E, Harbertson J, Kondrack R . Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J Exp Med. 2003; 197(7):875-83. PMC: 2193894. DOI: 10.1084/jem.20021290. View

Takamura S . Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells. Front Immunol. 2018; 9:1214. PMC: 5990602. DOI: 10.3389/fimmu.2018.01214. View

Swanson J, Hoppe A . The coordination of signaling during Fc receptor-mediated phagocytosis. J Leukoc Biol. 2004; 76(6):1093-103. DOI: 10.1189/jlb.0804439. View

Lau C, Adams N, Geary C, Weizman O, Rapp M, Pritykin Y . Epigenetic control of innate and adaptive immune memory. Nat Immunol. 2018; 19(9):963-972. PMC: 6225771. DOI: 10.1038/s41590-018-0176-1. View

Yuan H, Zhou S, Liu Z, Cong W, Fei X, Zeng W . Pivotal Role of Lesional and Perilesional T/B Lymphocytes in Pemphigus Pathogenesis. J Invest Dermatol. 2017; 137(11):2362-2370. DOI: 10.1016/j.jid.2017.05.032. View

Junt T, Moseman E, Iannacone M, Massberg S, Lang P, Boes M . Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007; 450(7166):110-4. DOI: 10.1038/nature06287. View

Brewer K, Weir G, Dude I, Davis C, Parsons C, Penwell A . Unique depot formed by an oil based vaccine facilitates active antigen uptake and provides effective tumour control. J Biomed Sci. 2018; 25(1):7. PMC: 5787234. DOI: 10.1186/s12929-018-0413-9. View

10.

Suan D, Krautler N, Maag J, Butt D, Bourne K, Hermes J . CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity. Immunity. 2017; 47(6):1142-1153.e4. DOI: 10.1016/j.immuni.2017.11.022. View

11.

Sirbulescu R, Boehm C, Soon E, Wilks M, Ilies I, Yuan H . Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions. Wound Repair Regen. 2017; 25(5):774-791. PMC: 5760362. DOI: 10.1111/wrr.12584. View

12.

Martin F, Kearney J . Marginal-zone B cells. Nat Rev Immunol. 2002; 2(5):323-35. DOI: 10.1038/nri799. View

13.

TIETZ W, Allemand Y, Borges E, von Laer D, Hallmann R, Vestweber D . CD4+ T cells migrate into inflamed skin only if they express ligands for E- and P-selectin. J Immunol. 1998; 161(2):963-70. View

14.

Kantele A, Savilahti E, Tiimonen H, Iikkanen K, Autio S, Kantele J . Cutaneous lymphocyte antigen expression on human effector B cells depends on the site and on the nature of antigen encounter. Eur J Immunol. 2003; 33(12):3275-83. DOI: 10.1002/eji.200324311. View

15.

Pascual V, Liu Y, Banchereau J . Normal human B cell sub-populations and their malignant counterparts. Baillieres Clin Haematol. 1998; 10(3):525-38. DOI: 10.1016/s0950-3536(97)80024-8. View

16.

Ballesteros-Tato A, Stone S, Lund F . Innate IFNγ-producing B cells. Cell Res. 2013; 24(2):135-6. PMC: 3915907. DOI: 10.1038/cr.2013.163. View

17.

Pasparakis M, Haase I, Nestle F . Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol. 2014; 14(5):289-301. DOI: 10.1038/nri3646. View

18.

Tan B, Peters A, Schleimer R, Hulse K . Pathogenic and protective roles of B cells and antibodies in patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2018; 141(5):1553-1560. PMC: 5942230. DOI: 10.1016/j.jaci.2018.03.002. View

19.

Kubach J, Hubo M, Amendt C, Stroh C, Jonuleit H . IgG1 anti-epidermal growth factor receptor antibodies induce CD8-dependent antitumor activity. Int J Cancer. 2014; 136(4):821-30. DOI: 10.1002/ijc.29037. View

20.

Ito T, Carson 4th W, Cavassani K, Connett J, Kunkel S . CCR6 as a mediator of immunity in the lung and gut. Exp Cell Res. 2011; 317(5):613-9. PMC: 3063449. DOI: 10.1016/j.yexcr.2010.12.018. View