Mechanisms Regulating Skin Immunity and Inflammation

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2014 Apr 12

PMID 24722477

Citations 353

Authors

Manolis Pasparakis

Ingo Haase

Frank O Nestle

Affiliations

Soon will be listed here.

Abstract

Immune responses in the skin are important for host defence against pathogenic microorganisms. However, dysregulated immune reactions can cause chronic inflammatory skin diseases. Extensive crosstalk between the different cellular and microbial components of the skin regulates local immune responses to ensure efficient host defence, to maintain and restore homeostasis, and to prevent chronic disease. In this Review, we discuss recent findings that highlight the complex regulatory networks that control skin immunity, and we provide new paradigms for the mechanisms that regulate skin immune responses in host defence and in chronic inflammation.

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