Ultraconserved Long Non-coding RNA Uc.112 is Highly Expressed in Childhood T Versus B-cell Acute Lymphoblastic Leukemia

Overview

Journal Hematol Transfus Cell Ther

Specialty Hematology

Date 2020 Feb 5

PMID 32014474

Citations 10

Authors

Pablo Ferreira das Chagas

Graziella Ribeiro de Sousa

Marcio Hideki Kodama

Carlos Alberto Oliveira de Biagi Junior

Jose Andres Yunes

Silvia Regina Brandalise

George Adrian Calin

Luiz Gonzaga Tone

Carlos Alberto Scrideli

Jaqueline Carvalho de Oliveira

Affiliations

Soon will be listed here.

Abstract

Aberrant expression of long non-coding RNAs (lncRNAs) has been detected in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA mapped on transcribed ultraconserved regions (T-UCRs) are little explored. The T-UCRs uc.112, uc.122, uc.160 and uc.262 were evaluated by quantitative real-time PCR in bone marrow samples from children with T-ALL (n=32) and common-ALL/pre-B ALL (n=30). In pediatric ALL, higher expression levels of uc.112 were found in patients with T-ALL, compared to patients with B-ALL. T-cells did not differ significantly from B-cells regarding uc.112 expression in non-tumor precursors from public data. Additionally, among B-ALL patients, uc.112 was also found to be increased in patients with hyperdiploidy, compared to other karyotype results. The uc.122, uc.160, and uc.262 were not associated with biological or clinical features. These findings suggest a potential role of uc.112 in pediatric ALL and emphasize the need for further investigation of T-UCR in pediatric ALL.

Citing Articles

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